Association Between Serum Vitamin D Levels and Uterine Leiomyomas: A Case-Control Study.
Background: Uterine leiomyomas (fibroids) are the most prevalent benign tumors among women of reproductive age and are associated with significant morbidity. According to recent data, vitamin D insufficiency may contribute to their onset and progression. Objectives: To examine the relationship betwe...
| Published in: | Journal of Nursing & Midwifery Sciences Vol. 13; no. 2; pp. 1 - 10 |
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| Main Authors: | , , , , |
| Format: | research tables/charts Journal Article |
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Brieflands
Jun2026
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=194527377&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 194527377 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23455756 HC3X jtl: Journal of Nursing & Midwifery Sciences issn: 23455756 maglogo: N pubinfo: dt: Jun2026 vid: 13 iid: 2 pid: 69510 pub: Brieflands place: , <Blank> artinfo: ui: 194527377 194527377 194527377 10.5812/jnms-166896 194527377 ppf: 1 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Association Between Serum Vitamin D Levels and Uterine Leiomyomas: A Case-Control Study. aug: au: Alizadeh, Roghieh Sharami, Seyedeh Reyhaneh Yousefi Hemmati, Zeinab Seyedoshohadaei, Fariba Soofizadeh, Nasrin affil: Department of Obstetrics and Gynecology, Kurdistan University of Medical Sciences, Sanandaj, Iran sug: subj: Vitamin D Blood Biological Markers Blood Vitamin D Deficiency Complications Leiomyoma Risk Factors Uterine Neoplasms Risk Factors Risk Assessment Premenopause Human Female Adult Case Control Studies Association (Research) Hospitals Iran Leiomyoma Ultrasonography Questionnaires Enzyme-Linked Immunosorbent Assay Endosonography Abdomen Ultrasonography Logistic Regression Chi Square Test T-Tests Data Analysis Software Descriptive Statistics Odds Ratio Confidence Intervals One-Way Analysis of Variance Convenience Sample Leiomyoma Epidemiology Adult: 19-44 years Female ab: Background: Uterine leiomyomas (fibroids) are the most prevalent benign tumors among women of reproductive age and are associated with significant morbidity. According to recent data, vitamin D insufficiency may contribute to their onset and progression. Objectives: To examine the relationship between uterine leiomyomas and blood vitamin D levels in premenopausal women. Methods: Between 2021 and 2022, a total of 200 women participated in this age-matched case-control study at Besat Hospital, Sanandaj, Iran. 100 women with ultrasound-confirmed leiomyomas (≥ 2 cm) were enrolled as cases, and 100 women without leiomyomas served as controls. To reduce measurement bias, all ultrasounds were performed by a single radiologist, and standardized morning blood sampling was used. Demographic data were collected via questionnaires, and serum 25-hydroxyvitamin D levels were quantified using the Arya Mabna enzyme-linked immunosorbent assay kit. Fibroid characteristics were assessed by transvaginal and abdominal ultrasound. Logistic regression, chi-square, and t -tests were applied in Stata 16. Results: Women with leiomyomas had a considerably lower mean blood vitamin D level than controls (19.96 ± 10.78 vs. 26.46 ± 13.29 ng/mL, P = 0.009). Vitamin D deficiency (< 20 ng/mL) was associated with a 3.5-fold higher risk of leiomyoma (OR = 3.5, 95% CI: 1.36 - 8.99). Mean fibroid volume was significantly greater among vitamin D-deficient women (236,757 ± 250,416 mm³) compared to those with sufficient levels (41,602 ± 65,573 mm³, P = 0.003). Vitamin D levels did not significantly correlate with the number or type of fibroid. Conclusions: Vitamin D deficiency is strongly associated with the presence and larger volume of uterine leiomyomas, although no significant correlations were found with fibroid type or number. These findings support the potential role of vitamin D supplementation as a preventive or therapeutic option. Larger prospective studies and randomized clinical trials are warranted to confirm these associations. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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