Observation of the Therapeutic Effect of Washed Microbiota Transplantation on Childhood Autism Spectrum Disorder.
Background: This retrospective study evaluated the efficacy and safety of washed microbiota transplantation (WMT) via trans colonic endoscopic administration tube for children with autism spectrum disorder (ASD). Methods: The clinical data of 19 children with ASD treated between November 2021 and De...
| Publicado en: | Actas Espanolas de Psiquiatria Vol. 54; no. 2; pp. 263 - 276 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
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Maria Lopez-Ibor
2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=194562688&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 194562688 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 11399287 IVZ jtl: Actas Espanolas de Psiquiatria issn: 11399287 maglogo: N pubinfo: dt: 2026 vid: 54 iid: 2 pid: 80014 pub: Maria Lopez-Ibor artinfo: ui: 194562688 10.62641/aep.v54i2.2120 ppf: 263 ppct: 13 formats: fmt: @attributes: type: P size: 2.9MB tig: atl: Observation of the Therapeutic Effect of Washed Microbiota Transplantation on Childhood Autism Spectrum Disorder. aug: au: Li, Jingwen Liu, Juan Chen, Mo Wang, Yi Zhou, Cheng affil: Department of Pediatrics, The Second People’s Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, 213003 Changzhou, Jiangsu, China. Microecology Center, The Second People’s Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, 213003 Changzhou, Jiangsu, China. Chengdu High-Tech Zhiji Future Clinical Medical Laboratory, 610000 Chengdu, Sichuan, China. Department of Neurology, Children’s Hospital of Fudan University, 201102 Shanghai, China. su: Fecal microbiota transplantation Autism spectrum disorders Probiotics Digestive system diseases Gut microbiota sug: subj: Fecal microbiota transplantation Autism spectrum disorders Probiotics Digestive system diseases Gut microbiota keyword: autism efficacy intestinal flora safety washed microbiota transplantation ab: Background: This retrospective study evaluated the efficacy and safety of washed microbiota transplantation (WMT) via trans colonic endoscopic administration tube for children with autism spectrum disorder (ASD). Methods: The clinical data of 19 children with ASD treated between November 2021 and December 2023 were analysed. The data included scores on the Autism Behaviour Checklist (ABC), Childhood Autism Rating Scale (CARS) and PedsQL™ 3.0 Gastrointestinal Symptoms Scales (PedsQL-GI) before treatment and one and six months post-WMT, as well as faecal 16S rRNA sequencing results (vs. healthy controls). Results: ABC, CARS and PedsQL-GI scores improved significantly over time (all p < 0.001, large effect sizes). CARS and PedsQL-GI scores decreased notably at one and six months after treatment. ABC scores reduced significantly only at six months posttreatment. PedsQLGI scores at six months posttreatment further declined relative to those atone month posttreatment, whereas ABC and CARS scores remained stable. Subgroup analysis showed greater score reductions in the high-score ASD and constipation subgroups than in other patients. Faecal microbiota analysis revealed structural differences between ASD and healthy children. WMT altered gut flora structure and increased beneficial bacteria (e.g., Faecalibacterium). Conclusions: Preliminary findings suggest that WMT may improve gastrointestinal and core symptoms in children with ASD, especially those in high-score subgroups. Caution is needed given this study’s small sample size, and large prospective studies are required for validation. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Actas Espanolas de Psiquiatria holder: Maria Lopez-Ibor dt: @attributes: year: 2026 holdings: @attributes: islocal: N |
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