The Role of Exosome-miRNA as Biomarkers of Alzheimer’s Disease: A Systematic Review of Case-Control and Longitudinal Studies.
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and its diagnosis remains challenging. Exosomal microRNAs (miRNAs), due to their stability, tissue specificity, and ability to cross the blood–brain barrier, show significant promise as ideal biomarkers for AD. The present study a...
| Publicado en: | Actas Espanolas de Psiquiatria Vol. 54; no. 2; pp. 556 - 568 |
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| Autores principales: | , , , , , |
| Formato: | Artículo |
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Maria Lopez-Ibor
2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=194562712&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 194562712 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 11399287 IVZ jtl: Actas Espanolas de Psiquiatria issn: 11399287 maglogo: N pubinfo: dt: 2026 vid: 54 iid: 2 pid: 80014 pub: Maria Lopez-Ibor artinfo: ui: 194562712 10.62641/aep.v54i2.2109 ppf: 556 ppct: 12 formats: fmt: @attributes: type: P size: 3.2MB tig: atl: The Role of Exosome-miRNA as Biomarkers of Alzheimer’s Disease: A Systematic Review of Case-Control and Longitudinal Studies. aug: au: Zhou, Haiqing Liu, Ying Li, Kaijun Mou, Shangdong Cao, Xia Chen, Qingjuan affil: Department of Infection Prevention and Control, 3201 Hospital, 723000 Hanzhong, Shaanxi, China. Department of Oncology, 3201 Hospital, 723000 Hanzhong, Shaanxi, China. Department of Oncology, The Zhenba County People’s Hospital, 723600 Hanzhong, Shaanxi, China. su: MicroRNA Biomarkers Neurodegeneration Alzheimer's disease Case-control method Longitudinal method Exosomes sug: subj: MicroRNA Biomarkers Neurodegeneration Alzheimer's disease Case-control method Longitudinal method Exosomes keyword: Alzheimer’s disease biomarkers exosomes neurodegenerative diseases ab: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and its diagnosis remains challenging. Exosomal microRNAs (miRNAs), due to their stability, tissue specificity, and ability to cross the blood–brain barrier, show significant promise as ideal biomarkers for AD. The present study aimed to systematically elucidate the relationship between the exosomal miRNA expression changes and AD pathogenesis (including Aβ deposition, Tau protein phosphorylation, and neuroinflammation) and to evaluate their potential utility in clinical screening and therapeutic interventions. A systematic literature search was conducted in the PubMed and Web of Science databases to identify human case–control or cohort studies reporting expressions of mature exosomal miRNAs in the serum, plasma, cerebrospinal fluid, saliva, or central nervous system cells. After evaluating the quality of the studies using the National Institutes of Health quality assessment tool, the identified differentially expressed miRNAs were summarized and functionally integrated. Among the 390 screened records, 48 studies (n = 3046 AD patients) met the inclusion criteria. The analysis identified 120 exosomal miRNAs that are differentially expressed at different AD ages. Six miRNAs (miR-125b, miR-146a, miR-193b, miR185-5p, miR-29b/c, miR-21-5p) were most consistently reported and showed significant correlation with AD pathology. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Actas Espanolas de Psiquiatria holder: Maria Lopez-Ibor dt: @attributes: year: 2026 holdings: @attributes: islocal: N |
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