Effects of Collagen Hydrolysate-Based Protein Complexes on Physical Endurance, Glucose Metabolism, and Renal Function in Rats.
Background/Objectives: The increasing prevalence of nutrition-related diseases and the limited availability of convenient, metabolically safe, high-protein foods represent a pressing public health challenge. This study aimed to evaluate the effects of four composite animal-derived high-protein ingre...
| Publicado en: | Nutrients Vol. 18; no. 11; pp. 1735 - 1759 |
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| Autores principales: | , , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
MDPI
Jun2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=194587430&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 194587430 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Jun2026 vid: 18 iid: 11 pid: 97109 pub: MDPI artinfo: ui: 194587430 194587430 194587430 10.3390/nu18111735 194587430 ppf: 1735 ppct: 24 formats: tig: atl: Effects of Collagen Hydrolysate-Based Protein Complexes on Physical Endurance, Glucose Metabolism, and Renal Function in Rats. aug: au: Kurkin, Denis V. Bakulin, Dmitry A. Osadchenko, Nazar A. Murina, Natalia S. Litvinova, Elena V. affil: Department of Pharmacy, Russian University of Medicine, Moscow 119049, Russia sug: subj: Collagen Pharmacodynamics Animal Proteins, Dietary Pharmacodynamics Physical Endurance Drug Effects Blood Glucose Metabolism Blood Glucose Drug Effects Kidney Physiology Kidney Drug Effects Eating Behavior Evaluation Carbohydrate Metabolism Drug Effects Behavior, Animal Drug Effects Dietary Supplementation Animal Studies Rats Funding Source Biotransformation Cattle Swine Whey Proteins Meat Blood Proteins Random Assignment Animal Proteins, Dietary Administration and Dosage Urea Drug Effects Urea Blood Creatinine Blood Creatinine Drug Effects Proteins Urine Proteins Drug Effects Glomerular Filtration Rate Drug Effects Physical Endurance Evaluation Biological Markers Drug Effects Proteinuria Prevention and Control Diet, High Protein Functional Food Swimming Fatigue Prevention and Control Chromatography, High Pressure Liquid Histology In Vitro Studies Data Analysis Software Descriptive Statistics One-Way Analysis of Variance Post Hoc Analysis Comparative Studies Biochemistry ab: Background/Objectives: The increasing prevalence of nutrition-related diseases and the limited availability of convenient, metabolically safe, high-protein foods represent a pressing public health challenge. This study aimed to evaluate the effects of four composite animal-derived high-protein ingredients based on collagen enzymatic hydrolysates on physical endurance, feeding behaviour, carbohydrate metabolism, renal function, and behavioural parameters in rats. Methods: Four lyophilised collagen hydrolysate-based ingredients were developed using enzymatic biotransformation of bovine and porcine raw materials, combined with bovine whey protein concentrate, bovine meat trim hydrolysate, porcine blood plasma proteins, and an api-component (Samples 1–4; protein content 87–89%). Ninety male Wistar rats were randomised into one control group and four experimental groups (n = 20 per experimental group, n = 10 controls) and received test samples by intragastric gavage at 3000 mg/kg/day for 40 days. Physical endurance was assessed via a weighted forced swimming test (days 0, 30, and 40); behavioural status by open field, adhesive removal, and marble burying tests; and biochemical parameters (blood glucose, serum urea, creatinine, urinary protein, and GFR) at days 0 and 40. Results: All experimental groups demonstrated a significant reduction in standard chow consumption (19–24%, p < 0.01) without affecting body weight gain. Physical endurance improved significantly in all groups relative to baseline, with the most pronounced effect in the Sample 3 group (+39% at day 40, p < 0.05). Blood glucose levels were significantly reduced across all groups (9–16%, p < 0.05). No adverse behavioural effects were observed. Biochemical markers indicated an adaptive rather than pathological renal response, with elevated GFR in three of four experimental groups (p < 0.05) and reduced proteinuria in the Sample 1 and Sample 3 groups. Conclusions: Forty-day administration of collagen hydrolysate-based protein complexes improved physical endurance and glucose metabolism, reduced food intake without compromising body weight, and did not impair renal function or behavioural status in healthy adult rats. These findings support the potential of such ingredients as functional food components, pending confirmation of long-term safety in extended studies. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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