Deciphering the Structure–Immunomodulatory Function Relationships of Homopolysaccharides.
Natural homopolysaccharides (HoPSs), composed of a single monosaccharide type, are increasingly recognized as bioactive macronutrients with broad relevance to nutrition and health. This review summarizes the extraction, structural characterization, and structure-immunomodulatory activity relationshi...
| Publicado en: | Nutrients Vol. 18; no. 11; pp. 1782 - 1807 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
MDPI
Jun2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=194587477&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 194587477 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Jun2026 vid: 18 iid: 11 pid: 97109 pub: MDPI artinfo: ui: 194587477 194587477 194587477 10.3390/nu18111782 194587477 ppf: 1782 ppct: 25 formats: tig: atl: Deciphering the Structure–Immunomodulatory Function Relationships of Homopolysaccharides. aug: au: Hu, Gege Yang, Bingyu Song, Han Zeng, Yuehan Zhang, Zhuoting Li, Yuwen Zhang, Jian Wang, Fenghuan affil: School of Light Industry Science and Engineering, Beijing Technology and Business University (BTBU), Beijing 100048, China sug: subj: Immune System Physiopathology Polysaccharides Pharmacodynamics Polysaccharides Analysis Molecular Structure Chemical Phenomena Carbohydrates Analysis Glycosides Analysis Monosaccharides Analysis Biological Products Signal Transduction Nutrition Allergy and Immunology NF-kappa B Mitogen-Activated Protein Kinases Gut Microbiota Metabolites Molecular Biology ab: Natural homopolysaccharides (HoPSs), composed of a single monosaccharide type, are increasingly recognized as bioactive macronutrients with broad relevance to nutrition and health. This review summarizes the extraction, structural characterization, and structure-immunomodulatory activity relationships of HoPSs. Drawing on a comprehensive synthesis of existing studies, we integrate current knowledge into a unified hierarchical framework of HoPS structure–function relationships. This framework organizes the literature into three hierarchical levels, including primary structural recognition, mid-level regulatory mechanisms, and functional refinement, while integrating key determinants such as molecular weight, glycosidic linkages, chain conformation, branching, and chemical modifications. By bridging structural glycomics and nutritional immunology, this framework synthesizes current evidence and provides a structured reference for future investigations. HoPSs exert well-established anti-infection and anti-inflammatory effects, alongside important nutritional and metabolic benefits. These outcomes are supported by evidence from cellular receptor signaling (e.g., TLRs, Dectin-1; NF-κB, MAPK pathways), gut microbiota remodeling, and metabolite network interactions. Finally, we discuss current research gaps, particularly in fine structural analysis and multidimensional mechanistic studies, and propose future directions based on precise structural elucidation, multidimensional structure–activity relationship modeling, and interdisciplinary integration. This review aims to bridge structural glycomics with human nutritional immunology, providing a theoretical basis for the structural optimization, immune activity enhancement, and functional food development of natural HoPSs to promote their industrial application in medicine, nutrition, and health. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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