Clinical Characteristics and Prognostic Risk Factors in Breast Cancer With Liver Metastasis.
Background: Liver metastasis is a key adverse prognostic factor in breast cancer patients. This research was aimed to assess the development, risk factors, and prognostic determinants of breast cancer liver metastasis (BCLM). Methods: We retrospectively analyzed the data of breast cancer from the Su...
| Published in: | Breast Journal Vol. 2026; pp. 1 - 13 |
|---|---|
| Main Authors: | , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
6/20/2026
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=194723531&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 194723531 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1075122X ET6 jtl: Breast Journal issn: 1075122X maglogo: Y pubinfo: dt: 6/20/2026 vid: 2026 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 194723531 194723531 194723531 10.1155/tbj/5088737 194723531 ppf: 1 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Clinical Characteristics and Prognostic Risk Factors in Breast Cancer With Liver Metastasis. aug: au: Yu, Dandan Zhu, Chengjun Yang, Sujin Wang, Dandan Guan, Xiaoxiang Dattachoudhury, Sreeja affil: Department of Radiation Oncology,, The First Affiliated Hospital of Nanjing Medical University,, Nanjing, 210029,, China, njmu.edu.cn sug: subj: Breast Neoplasms Epidemiology Neoplasm Metastasis Epidemiology Liver Neoplasms Epidemiology Breast Neoplasms Prognosis Neoplasm Metastasis Prognosis Liver Neoplasms Prognosis Breast Neoplasms Risk Factors Neoplasm Metastasis Risk Factors Liver Neoplasms Risk Factors Disease Attributes Risk Assessment Funding Source China Human Retrospective Design Incidence Multiple Logistic Regression Overall Survival Kaplan-Meier Estimator Cox Proportional Hazards Model Age Factors Epidermal Growth Factor Receptors Descriptive Statistics Liver Neoplasms Surgery Neoplasm Grading Odds Ratio Confidence Intervals Data Analysis Software Bone Metastases Lung Neoplasms Brain Neoplasms Adolescence Adult Middle Age Aged Aged, 80 and Over Female Race Factors Marital Status Mortality Risk Factors Multivariate Analysis Univariate Statistics Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female ab: Background: Liver metastasis is a key adverse prognostic factor in breast cancer patients. This research was aimed to assess the development, risk factors, and prognostic determinants of breast cancer liver metastasis (BCLM). Methods: We retrospectively analyzed the data of breast cancer from the Surveillance, Epidemiology, and End Results (SEER) (N = 560,908) and Jiangsu Province Hospital (JSPH) database (N = 294). The risk factors for BCLM were identified via multivariate logistic regression, and overall survival (OS) was assessed with Kaplan–Meier (KM) survival curves and Cox regression models. Results: In the SEER cohort, liver metastasis attacked 1.3% of patients, and the highest incidence was found in the HR−/HER2+ subtype (4.4%). The risk factors for BCLM include young age, high pathological grade, concurrent bone, lung or brain metastasis, and HER2‐positive or triple‐negative subtype. The median OS of BCLM patients was short (SEER: 22 months; JSPH: 33.5 months). OS was shorter in patients with concomitant metastasis to other organs or with HER2‐negative subtype. Hepatic resection remarkably prolonged survival (SEER: 90 vs. 35 months; JSPH: not reached vs. 31.3 months). In the JSPH cohort, molecular subtype changed in 27.5% of patients during metastasis. Conclusions: The occurrence of BCLM is affected by age, tumor grade, other organ involvement, and molecular subtype. Survival was improved in BCLM patients with liver‐only metastasis, HER2‐positive subtype, or those who underwent hepatic resection. The number and molecular characteristics of liver metastasis are important prognostic predictors, and receptor conversion highlights the need for reassessment of therapeutic strategies during metastatic progression. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|