Partial Differential Equation (PDE)‐Based Spatial Pharmacometrics in NONMEM: Method of Lines (MOL) Implementation with AI‐Assisted Model Development.
Spatial heterogeneity in drug distribution, particularly within solid tumors, compromises target engagement, yet is rarely represented in population pharmacokinetic analyses. Standard "well‐stirred" models fail to capture intratumoral gradients. Reaction–diffusion partial differential equations (PDE...
| Published in: | Journal of Clinical Pharmacology Vol. 66; no. 6; pp. 1 - 12 |
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| Main Authors: | , |
| Format: | equations & formulas tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Jun2026
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| Online Access: | View this record in EBSCOhost |