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An Exploration of the Intersection of Clinical Trials and Health Literacy: A Scoping Review.

This scoping review synthesizes findings from 25 articles examining health literacy (HL) and clinical trials (CTs). Key factors contributing to low HL include poverty, limited education, older age, and limited English proficiency. Three thematic categories emerged: 1) barriers to recruitment and par...

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Published in:Journal of Health Care for the Poor & Underserved Vol. 37; no. 2; pp. 466 - 493
Main Authors: Rashev, rgarita, rdini, Ali
Format: research systematic review tables/charts Journal Article
Published: Johns Hopkins University Press May2026
Online Access:View this record in EBSCOhost
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        10492089
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      dt: May2026
      vid: 37
      iid: 2
      pid: 226
      pub: Johns Hopkins University Press
      place: Baltimore, Maryland
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        194878405
        194878405
        194878405
        10.1353/hpu.2026.a992761
        194878405
      ppf: 466
      ppct: 27
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        atl: An Exploration of the Intersection of Clinical Trials and Health Literacy: A Scoping Review.
      aug:
        au:
          Rashev, rgarita
          rdini, Ali
        affil: Denotes co-second authorship
      sug:
        subj:
          Health Literacy
          Clinical Trials
          Research Subject Recruitment
          Research Subject Retention
          Patient Compliance
          Intersectionality
          Human
          Scoping Review
          Poverty
          Educational Status
          Age Factors
          Limited English Proficiency
          Thematic Analysis
          Medically Underserved Psychosocial Factors
          Motion Pictures
          Consent (Research)
          Conceptual Framework
          Medline
          Cochrane Library
          Embase
          Psycinfo
          Male
          Female
          Adolescence
          Adult
          Middle Age
          Aged
          Aged, 80 and Over
          Funding Source
          Adolescent: 13-18 years
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Aged: 65+ years
          Aged, 80 & over
          Male
          Female
      ab: This scoping review synthesizes findings from 25 articles examining health literacy (HL) and clinical trials (CTs). Key factors contributing to low HL include poverty, limited education, older age, and limited English proficiency. Three thematic categories emerged: 1) barriers to recruitment and participation, 2) perceptions and comprehension of CT processes, and 3) interventions to improve knowledge and participation. Health literacy was found to influence willingness to participate in CTs, with higher HL associated with greater participation, especially in lower-burden trials. Misconceptions about CTs were prevalent among underserved populations. Interventions such as animated videos and simplified consent forms showed mixed effectiveness. A mapping exercise revealed gaps in existing HL frameworks, including provider bias and lack of target population involvement in trial design. Addressing these gaps through inclusive, culturally responsive strategies may improve comprehension, trust, and participation among underserved populations. Further research is needed to refine and evaluate HL interventions across CT contexts.
      pubtype: Academic Journal
      doctype:
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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