Miliseol A–D: new lanostane triterpenoids from Miliusa sessilis and their wound-healing activity.
Investigation of the Miliusa sessilis hexane extract led to four novel lanostane triterpenoids, miliseol A–D (1–4) and five known compounds (5–9). Through extensive spectroscopic analyses, the new compounds were identified as (3β,23S)-23-methoxy-24-methylene-29-nor-5α-lanost-9(11)-en-3-ol (1), (3β,2...
| Publicado en: | Natural Product Research Vol. 40; no. 13; pp. 3926 - 3936 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jul2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=194999901&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 194999901 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: Jul2026 vid: 40 iid: 13 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 194999901 184429813 10.1080/14786419.2025.2491834 194999901 ppf: 3926 ppct: 10 formats: tig: atl: Miliseol A–D: new lanostane triterpenoids from Miliusa sessilis and their wound-healing activity. aug: au: Pootaeng-on, Yupa Sirirak, Jitnapa Yodsin, Nuttapon Kuntiyong, Punlop Charoensuksai, Purin Wongprayoon, Pawaris Jiajaroen, Suwadee Chainok, Kittipong Rayanil, Kanok-on affil: Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom, Thailand sug: ab: Investigation of the Miliusa sessilis hexane extract led to four novel lanostane triterpenoids, miliseol A–D (1–4) and five known compounds (5–9). Through extensive spectroscopic analyses, the new compounds were identified as (3β,23S)-23-methoxy-24-methylene-29-nor-5α-lanost-9(11)-en-3-ol (1), (3β,23S)-23-methoxy-24-methylene-5α-lanost-9(11)-en-3-ol (2), (3β,16β)-24-methylene-5α-lanost-9(11)-ene-3,16-diol (3), and (3β,24S)-24,241-epoxy-5α-lanost-9(11)-en-3-ol (4). The density functional theory (DFT) computations combined with a statistical procedure (DP4+) were used to identify the stereochemistry of compound 4. The X-ray crystallographic data was utilised to confirm the absolute configurations of compounds 1 and 3. The known compounds were isolated and elucidated as (+)-spathulenol (5), phytol (6), T-muurolol (7), β-sitosterol (8), and β-sitosterol-3-O-β-d-glucopyranoside (9) through spectroscopic analyses and comparison with the literature. Biological activity screening indicated that compound 1 promoted cell migration in the HaCaT cell line, with minimal cytotoxicity at the tested concentrations. This finding suggests its potential as an enhancing agent for skin wound healing. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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