Evaluation of Serum Long Non-Coding RNAs HOXA Transcript at the Distal Tip (HOTTIP), Colon Cancer–Associated Transcript 1 (CCAT1), and Colon Cancer–Associated Transcript 2 (CCAT2) as Potential Biomarkers in Schizophrenia.
Background: Schizophrenia (SZ) is a chronic neuropsychiatric disorder with marked impairments in cognitive, behavioral, and emotional functions. Despite extensive research, reliable molecular biomarkers of the disease have not yet been identified. Long non-coding RNAs (lncRNAs) stand out as regulato...
| Publicado en: | Eurasian Journal of Medicine Vol. 58; no. 4; pp. 1 - 7 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Aves Yayincilik A.S.
Dec2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195037185&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195037185 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13088734 BAPO jtl: Eurasian Journal of Medicine issn: 13088734 maglogo: N pubinfo: dt: Dec2026 vid: 58 iid: 4 pid: 47039 pub: Aves Yayincilik A.S. artinfo: ui: 195037185 195037185 195037185 10.5152/eurasianjmed.2026.251271 195037185 ppf: 1 ppct: 6 formats: tig: atl: Evaluation of Serum Long Non-Coding RNAs HOXA Transcript at the Distal Tip (HOTTIP), Colon Cancer–Associated Transcript 1 (CCAT1), and Colon Cancer–Associated Transcript 2 (CCAT2) as Potential Biomarkers in Schizophrenia. aug: au: Güzel Tanoğlu, Esra Çevik, Filiz Ekim Çakmur, Kadriye Nur Esen, Muhammed Fevzi Uzun, Fatma Rumeysa Erkıran, Murat affil: Department of Molecular Biology and Genetics, Institution of Hamidiye Medical Sciences, University of Health Sciences, İstanbul, Türkiye sug: subj: Schizophrenia Blood Schizophrenia Familial and Genetic Colonic Neoplasms Blood Colonic Neoplasms Familial and Genetic RNA Blood Biological Markers Blood Gene Expression Human Male Female Adult Middle Age Case Control Studies Reverse Transcriptase Polymerase Chain Reaction Quality of Care Research Sensitivity and Specificity Descriptive Statistics Comparative Studies Post Hoc Analysis ROC Curve Mann-Whitney U Test Spearman's Rank Correlation Coefficient Data Analysis Software Confidence Intervals Cognition Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: Schizophrenia (SZ) is a chronic neuropsychiatric disorder with marked impairments in cognitive, behavioral, and emotional functions. Despite extensive research, reliable molecular biomarkers of the disease have not yet been identified. Long non-coding RNAs (lncRNAs) stand out as regulatory molecules with diagnostic potential in many neurological and psychiatric disorders. This study aimed to evaluate the serum levels of HOXA transcript at the distal tip (HOTTIP), colon cancer–associated transcript 1 (CCAT1), and CCAT2 lncRNAs as potential biomarkers in SZ. Methods: Seventy antipsychotic-naive patients with SZ and 55 healthy controls participated in the study from June 2023 to May 2024. Control and SZ serum samples were collected, and the relative expression levels of HOTTIP, CCAT1, and CCAT2 were analyzed using reverse transcription-quantitative polymerase chain reaction. Results: Results showed that HOTTIP expression was significantly increased in patients with SZ (P <.05). However, no significant difference was observed in CCAT1 and CCAT2 levels between the groups. The association between increased HOTTIP levels and clinical symptom profiles suggests that this molecule may be linked to disease activity and SZ response. The HOTTIP showed modest discriminative ability (AUC = 0.60, 95% CI 0.50-0.70). Conclusion: : The study was powered to detect moderate group differences; the null results for CCAT1/CCAT2 therefore exclude moderate-or-larger effects but not small effects. HOTTIP may represent a noninvasive biological marker associated with SZ, although its standalone diagnostic utility appears limited. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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