| Sumario: | The article focuses on the current state and future directions of pressure ulcer (PU) research, highlighting that despite over 5,100 publications from 2002 to 2021, PUs remain a significant patient safety issue worldwide. It emphasizes the need for more robust primary studies, particularly high-quality randomized controlled trials, to strengthen clinical guidelines. Key priorities for future research include developing objective early detection methods such as sub-epidermal moisture (SEM) assessment and artificial intelligence, investigating pain as an early indicator, enhancing implementation science to improve evidence-based practice, and ensuring patient involvement and equity across diverse populations. Additionally, digital innovations and even space medicine are identified as emerging areas with potential to advance PU prevention and management.
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