Frailty-related multiple health outcomes in older individuals: an umbrella review of systematic reviews and meta-analyses.
Frailty and its subtypes including physical, cognitive, multidimensional and social frailty have been reported to be associated with a wide range of adverse outcomes in older adults. However, little effort has been made to collate and assess the credibility of this evidence. The aim of this umbrella...
| Publicado en: | Age & Ageing Vol. 55; no. 6; pp. 1 - 18 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
| Publicado: |
Oxford University Press / USA
Jun2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=195099705&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 195099705 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jun2026 vid: 55 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 195099705 10.1093/ageing/afag145 ppf: 1 ppct: 17 formats: tig: atl: Frailty-related multiple health outcomes in older individuals: an umbrella review of systematic reviews and meta-analyses. aug: au: Yu, Yawei Guo, Hong Li, Ziye Lv, Ziwei Chen, Yiping affil: Beijing University of Chinese Medicine, Beijing, Beijing, China Peking Union Medical College Hospital, Beijing, Beijing, China su: Mental depression risk factors Mortality Institutional care Hospital care of older people Disease risk factors Old age Dementia risk factors Cognition disorder risk factors Research funding Frail elderly Systematic reviews Bone fractures Accidental falls sug: subj: Mental depression risk factors Mortality Institutional care Hospital care of older people Disease risk factors Old age Other Residential Care Facilities Residential Mental Health and Substance Abuse Facilities Dementia risk factors Cognition disorder risk factors Research funding Frail elderly Systematic reviews Bone fractures Accidental falls keyword: aged copyrightHolder:British Geriatrics Society copyrightYear:2026 frailty health outcomes https://dx.doi.org/10.1093/ageing/afag145 inLanguage:en mortality older adults outcomes publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/42234808/ systematic review umbrella review aged copyrightHolder:British Geriatrics Society copyrightYear:2026 frailty health outcomes https://dx.doi.org/10.1093/ageing/afag145 inLanguage:en mortality older adults outcomes publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/42234808/ systematic review umbrella review ab: Frailty and its subtypes including physical, cognitive, multidimensional and social frailty have been reported to be associated with a wide range of adverse outcomes in older adults. However, little effort has been made to collate and assess the credibility of this evidence. The aim of this umbrella review was to systematically evaluate the certainty of associations between frailty subtypes and adverse health outcomes across community, nursing home and hospital settings. We registered an a priori protocol with PROSPERO (CRD420251123204) and searched five databases from inception to August 2025. We included 37 systematic reviews and meta-analyses. Methodological quality was assessed using a measurement tool to assess systematic reviews (AMSTAR) 2. Evidence credibility was evaluated using predefined statistical criteria. Non-pooled outcomes were judged by the grading of recommendations assessment, development, and evaluation (GRADE) approach. A total of 31 frailty-related outcomes and 11 prefrailty-related outcomes were identified, with a corrected covered area of 0.98%. Pooled analyses showed suggestive evidence for associations of frailty with mortality (pooled relative risk (RR) 2.07) and prefrailty with mortality (pooled RR 1.38). Frailty was also associated with higher risks of hospitalisation, institutionalisation, falls, fractures, cognitive decline and depression. Cognitive frailty showed a markedly elevated risk of dementia (pooled RR 3.75). Multidimensional frailty had the highest mortality risk. Social frailty was associated with mortality and functional decline. Hospital-based evidence indicated that frailty predicted delirium, in-hospital death and post-discharge mortality. Although most non-pooled outcomes presented low to moderate certainty, the direction of effects was consistent. These findings support early detection and multidimensional management of frailty, particularly cognitive and social frailty. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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