Parkinsonian signs and cognitive trajectories in older adults: a population-based longitudinal study.
Introduction Cognitive impairment is common in parkinsonian disorders, but its extent among older adults with subtle motor abnormalities without a diagnosed movement disorder remains unclear. We examined cognitive decline, domain-specific cognitive function and incident dementia in older adults with...
| Publicado en: | Age & Ageing Vol. 55; no. 6; pp. 1 - 9 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Jun2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=195099710&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 195099710 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jun2026 vid: 55 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 195099710 10.1093/ageing/afag160 ppf: 1 ppct: 8 formats: tig: atl: Parkinsonian signs and cognitive trajectories in older adults: a population-based longitudinal study. aug: au: Algotsson, Charlotte Overton, Marieclaire Basna, Rani ElmstÅHl, SöLve Siennicki-Lantz, Arkadiusz affil: Division of Geriatric Medicine, Department of Clinical Sciences in Malmö, Lund University, Malmö, Skåne County, Sweden su: Sweden Language & languages Executive function Aging Cognition Disease risk factors Dementia risk factors Cognition disorder risk factors Risk assessment Independent living Research funding Cognitive processing speed Analysis of covariance Descriptive statistics Longitudinal method Parkinsonian disorders Neuropsychological tests Comparative studies Data analysis software Short-term memory Confidence intervals Memory disorders Proportional hazards models Disease incidence Time Disease complications sug: subj: Language & languages Executive function Aging Cognition Disease risk factors Sweden Dementia risk factors Cognition disorder risk factors Risk assessment Independent living Research funding Cognitive processing speed Analysis of covariance Descriptive statistics Longitudinal method Parkinsonian disorders Neuropsychological tests Comparative studies Data analysis software Short-term memory Confidence intervals Memory disorders Proportional hazards models Disease incidence Time Disease complications keyword: aged aging cognition cognitive ability cognitive dysfunction cognitive impairment copyrightHolder:British Geriatrics Society copyrightYear:2026 dementia dementia/epidemiology executive functioning follow-up https://dx.doi.org/10.1093/ageing/afag160 inLanguage:en languages longitudinal studies memory movement disorders older adults parkinson disease parkinsonian disorders parkinsonism publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/42258775/ sensitivity analysis unified parkinson's disease rating scale aged aging cognition cognitive ability cognitive dysfunction cognitive impairment copyrightHolder:British Geriatrics Society copyrightYear:2026 dementia dementia/epidemiology executive functioning follow-up https://dx.doi.org/10.1093/ageing/afag160 inLanguage:en languages longitudinal studies memory movement disorders older adults parkinson disease parkinsonian disorders parkinsonism publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/42258775/ sensitivity analysis unified parkinson's disease rating scale ab: Introduction Cognitive impairment is common in parkinsonian disorders, but its extent among older adults with subtle motor abnormalities without a diagnosed movement disorder remains unclear. We examined cognitive decline, domain-specific cognitive function and incident dementia in older adults with subthreshold parkinsonism and parkinsonism (primary analysis). Sensitivity analyses were repeated using an additional definition of Mild Parkinsonian Signs for comparison. Methods In the longitudinal general-population study Good Ageing in Skåne, 398 older adults aged 80–101 years (mean 86) were examined using the Unified Parkinson's Disease Rating Scale part III and a comprehensive cognitive test battery. Participants were followed for a mean of 2.67 (0–9) years. Linear mixed models adjusted for age, sex and education were used to examine cognitive trajectories. Results At baseline, 54.4% of participants met the criteria for subthreshold parkinsonism and 23.6% for parkinsonism. Subthreshold parkinsonism was associated with reduced performance in perceptual speed (z -score estimate: −0.51), language (−0.36), executive function (−0.36) and global cognition (−0.33). Parkinsonism was associated with reduced performance in memory (−0.30), perceptual speed (−0.40), language (−0.33), executive function (−0.32) and global cognition (−0.34). Memory decline was most pronounced in both groups. During follow-up, 18% of participants developed dementia; of these, 46% had subthreshold parkinsonism and 26% parkinsonism at baseline. Conclusion Subthreshold parkinsonism and parkinsonism are associated with cognitive impairment, particularly perceptual speed, language, executive function and global cognition that progress over time. These findings support parkinsonian signs as a prodromal state and highlight the importance of early detection for dementia prevention. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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