Risk of dementia after bloodstream infection—a nationwide propensity score matched cohort study.
Background Dementia is a global public health threat. Current treatments have limited efficacy, making identification of modifiable risk factors of paramount importance. Observational studies link severe infections to increased dementia risk but often suffer confounding. Here, we address this by det...
| Publicado en: | Age & Ageing Vol. 55; no. 6; pp. 1 - 10 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Jun2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=195099726&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 195099726 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jun2026 vid: 55 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 195099726 10.1093/ageing/afag178 ppf: 1 ppct: 9 formats: tig: atl: Risk of dementia after bloodstream infection—a nationwide propensity score matched cohort study. aug: au: Underwood, Jonathan Farewell, Daniel Gillespie, David Harrison, Neil A Ahmed, Haroon affil: Division of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UKDepartment of Infectious Diseases, Cardiff and Vale University Health Board, Cardiff CF14 4XW, UK Division of Population Medicine, Cardiff University, Cardiff CF14 4XN, UK Centre for Trials Research, Cardiff University, Cardiff, Wales, UK Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, Wales, UK su: United Kingdom Hospital care Smoking Retrospective studies Alcoholism Obesity Dementia risk factors Risk assessment Frail elderly Questionnaires Descriptive statistics Longitudinal method Sepsis Medical records Acquisition of data Inflammation Data analysis software Confidence intervals Proportional hazards models Disease complications sug: subj: Hospital care Smoking Retrospective studies Alcoholism Obesity United Kingdom Dementia risk factors Risk assessment Frail elderly Questionnaires Descriptive statistics Longitudinal method Sepsis Medical records Acquisition of data Inflammation Data analysis software Confidence intervals Proportional hazards models Disease complications keyword: bloodstream infection bloodstream infections cohort study copyrightHolder:British Geriatrics Society copyrightYear:2026 dementia https://dx.doi.org/10.1093/ageing/afag178 inLanguage:en older people propensity score matching publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/42328806/ sepsis bloodstream infection bloodstream infections cohort study copyrightHolder:British Geriatrics Society copyrightYear:2026 dementia https://dx.doi.org/10.1093/ageing/afag178 inLanguage:en older people propensity score matching publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/42328806/ sepsis ab: Background Dementia is a global public health threat. Current treatments have limited efficacy, making identification of modifiable risk factors of paramount importance. Observational studies link severe infections to increased dementia risk but often suffer confounding. Here, we address this by determining dementia risk following bloodstream infection (BSI) in a nationwide study. Methods We conducted a cohort study within the Secure Anonymised Information Linkage Databank, containing anonymised population-scale electronic health record data for the population of Wales, UK. Patients with microbiologically confirmed BSI were propensity score matched 1:1 to controls (n = 2.5 million without dementia at baseline). We created two comparative models to estimate the true effect of BSI on dementia risk: modelling hospitalisation with sterile inflammation, uncomplicated total knee replacement (TKR) replaced BSI as the exposure; assessing residual confounding, lung cancer replaced dementia as outcome. Results We included 26 792 people with BSI and 26 792 matched controls, all without dementia at cohort entry. BSI was associated with an increased cumulative hazard of dementia corresponding to 160 (128–182) additional cases per 1000 person-years 10 years after exposure. TKR was not associated with an increased risk of dementia. BSI was potentially associated with a small excess hazard of lung cancer [12.4 (5.4–19.5) additional cases per 1000 person-years 10 years after exposure]. Conclusions BSI was associated with incident dementia in excess of that expected by hospitalisation or residual confounding. These findings suggest that treatment of BSI and other severe infections merits further investigation as a potentially modifiable risk factor for dementia. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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