Effect of antihypertensive medication reduction on short-term blood pressure control in older adults: calibration of OPTiMISE trial results to real-world primary care data.

Background While antihypertensive treatment prevents cardiovascular events, it may also increase risks such as falls in patients with frailty. The Optimising Treatment for Mild Systolic Hypertension in the Elderly (OPTiMISE) trial found that deprescribing one antihypertensive drug did not result in...

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Bibliographic Details
Published in:	Age & Ageing Vol. 55; no. 6; pp. 1 - 10
Main Authors:	Christiaens, Antoine, Wang, Ariel, McAllister, David A, McManus, Richard J, Sheppard, James P
Format:	Article
Published:	Oxford University Press / USA Jun2026
Subjects:	England Primary health care Hypertension Hospital care Old age Research funding Secondary analysis Antihypertensive agents Deprescribing Treatment effectiveness Descriptive statistics Data analysis software Confidence intervals Calibration Proportional hazards models Regression analysis Evaluation
Online Access:	View this record in EBSCOhost