Exploring the Impact of Reduction in Methamphetamine Use on Sexual Risk Behaviors Among Men Who Have Sex with Men and Women: Findings from the ADAPT- 2 Trial.
Background: Methamphetamine (MA) use has been linked to engaging in sexual risk behaviors (SRBs) that are associated with HIV/STIs, particularly among men who have sex with men (MSM) and men who have sex with men and women (MSMW; hereafter MSM/W). The objectives of this analysis were to determine wh...
| Publicado en: | International Journal of Behavioral Medicine Vol. 33; no. 3; pp. 487 - 494 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195149276&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195149276 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10705503 7M2 jtl: International Journal of Behavioral Medicine issn: 10705503 maglogo: N pubinfo: dt: Jun2026 vid: 33 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 195149276 184291643 195149276 195149276 10.1007/s12529-025-10364-z 195149276 ppf: 487 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Exploring the Impact of Reduction in Methamphetamine Use on Sexual Risk Behaviors Among Men Who Have Sex with Men and Women: Findings from the ADAPT- 2 Trial. aug: au: Okafor, Chukwuemeka N. Yoon, Jin H Jean-Berluche, Ducel Mayes, Taryn L. Shoptaw, Steve Trivedi, Madhukar H. Potter, Jennifer S Schmitz, Joy affil: https://ror.org/02f6dcw23 Department of Medicine, Division of Infectious Diseases, Long School of Medicine, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, 78229-3900, San Antonio, TX, USA sug: subj: Men Who Have Sex With Men Psychosocial Factors Bisexual Persons Psychosocial Factors Sexual Behavior Risk Taking Behavior Methamphetamine Substance Use Disorders Funding Source Human Male Adult Middle Age Secondary Analysis Substance Abuse Detection Poisson Distribution Regression Odds Ratio Confidence Intervals Data Analysis Software Descriptive Statistics Sexual Partners Unsafe Sex Condoms Harm Reduction Adult: 19-44 years Middle Aged: 45-64 years Male ab: Background: Methamphetamine (MA) use has been linked to engaging in sexual risk behaviors (SRBs) that are associated with HIV/STIs, particularly among men who have sex with men (MSM) and men who have sex with men and women (MSMW; hereafter MSM/W). The objectives of this analysis were to determine whether reduced MA is associated with decreases in SRBs in a sample of MSM/W. Method: Data came from the ADAPT- 2 trial, a randomized, double-blind, two-stage sequential parallel design trial evaluating extended-release injectable naltrexone (NTX) and oral bupropion (BUP) vs. placebo for MA use disorder. In the first 6 weeks of the trial (stage 1), participants were randomized to receive NTX-BUP or placebo. In the second 6 weeks, participants in the placebo group who did not have a treatment response were rerandomized (stage 2). For this secondary analysis, the independent variable was the number of MA-negative urine drug screens (UDS). The dependent variables included three different types of SRBs. Regression models of the independent and dependent variables were adjusted for age, race/ethnicity status, marital status, treatment assignment, and baseline SRBs. Results: Of the 151 participants, median age was 40 years and majority were non-Hispanic white (52%) and completed more than high school education (82%). Each additional MA-negative UDS was associated with a 7% (adjusted rate ratio (aRR) = 0.93; 95% CI, 0.87, 0.99) reduction in total number of sex partners in stage 2 only. Each additional MA-negative UDS was associated with a 13% (aRR = 0.87 95%; confidence interval (CI), (0.76, 0.98)) and 9% (aRR = 0.91; 95% CI, 0.84, 0.99) reduction in number of condomless sexual encounters in stage 1 and stage 2, respectively. Lastly, each additional MA-negative UDS was associated with a 16% (aRR = 0.84; 95% (CI), 0.75, 0.94)) and 27% (aRR = 0.73; 95% CI, 0.64, 0.84) reduction in number of sexual encounters when high on MA. Conclusion: Our analysis showed that reductions in MA use was associated with reductions in several sexual risk behaviors associated with HIV/STI. These findings provide further support for exploring reductions in sexual risk behaviors as a clinical endpoint in future treatment interventions for MA use. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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