Reducing intracerebral hemorrhage in traumatic brain injury: Therapeutic hypothermia and intranasal insulin.
Background: Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. It consists of a primary insult that leads to secondary damage. Current TBI interventions primarily do not focus on preventive measures to improve the outcome of secondary brain injury, especially in the p...
| Publicado en: | Archives of Trauma Research Vol. 15; no. 1; pp. 26 - 33 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Kashan University of Medical Sciences
Spring2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195173134&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195173134 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2251953X GXL0 jtl: Archives of Trauma Research issn: 2251953X maglogo: N pubinfo: dt: Spring2026 vid: 15 iid: 1 pid: 93700 pub: Kashan University of Medical Sciences artinfo: ui: 195173134 195173134 195173134 10.48307/atr.2026.484241.1167 195173134 ppf: 26 ppct: 7 formats: tig: atl: Reducing intracerebral hemorrhage in traumatic brain injury: Therapeutic hypothermia and intranasal insulin. aug: au: Mousavi, Shahrokh Jahromi, Hadi Moatamed Rafati, Ali Zolpirani, Ardeshir Nabizadeh Ghaffari, Mahdi Khorsand affil: Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran sug: subj: Brain Injuries Therapy Cerebral Hemorrhage Prevention and Control Hypothermia, Induced Methods Insulin Therapeutic Use Administration, Intranasal Treatment Outcomes Animal Studies Models, Biological Rats Random Assignment Descriptive Statistics Comparative Studies Histological Techniques Programming Languages Brain Physiology Tissue Analysis Brain Injuries Complications Analysis of Variance Kruskal-Wallis Test Mann-Whitney U Test Two-Way Analysis of Variance Repeated Measures Data Analysis Software Quantitative Studies Funding Source ab: Background: Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. It consists of a primary insult that leads to secondary damage. Current TBI interventions primarily do not focus on preventive measures to improve the outcome of secondary brain injury, especially in the prehospital setting. Objectives: This study aimed to investigate the potential of therapeutic hypothermia and intranasal insulin to reduce secondary damage and prevent cerebral hemorrhage following TBI. Methods: Rats were randomly assigned to five groups: sham, TBI, TBI with insulin treatment, TBI with hypothermia treatment, and TBI with combined hypothermia and insulin treatment. Brain tissues were analyzed using histomorphological and stereological methods. Statistical analysis was conducted using the Python programming language. Results: Histomorphological analysis of brain tissue revealed no significant differences in ventricular volumes among groups. However, hemorrhages were observed, with the TBI group showing the highest hemorrhage volume. The hypothermia group showed a higher intracerebral hemorrhage compared to the sham and combined treatment groups, while the insulin group had significantly more hemorrhage than the sham group. Conclusion: Therapeutic hypothermia and intranasal insulin showed potential in reducing intracerebral hemorrhage volume post-TBI. Further research, including human clinical trials, is needed to validate these findings. This study underscores the potential benefits of therapeutic hypothermia and intranasal insulin in managing TBI-related hemorrhage and warrants further investigation. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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