Cover Image
QR Code

Integrative Analysis of Clinical Features and Cerebrospinal Fluid Immune Microenvironment in Leptomeningeal Metastasis From Non-small-cell Lung Cancer Patients.

Background: Leptomeningeal metastasis (LM) represents one of the most severe complications in advanced lung cancer, indicating a poor prognosis. However, the mechanisms underlying LM progression remain incompletely understood, and reliable biomarkers for monitoring disease progression and treatment...

Full description

Published in:Clinical Medicine Insights: Oncology Vol. 20; pp. 1 - 12
Main Authors: Chen, Junjun, Zhou, Qihao, Yin, Yuan, Qin, Zhiquan, Chen, Yun
Format: research tables/charts Journal Article
Published: Sage Publications Inc. 7/7/2026
Online Access:View this record in EBSCOhost
fields @attributes:
  recordID: 1
pdfLink:
plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195176268&site=ehost-live
header:
  @attributes:
    shortDbName: ccm
    uiTerm: 195176268
    longDbName: CINAHL Complete
    uiTag: AN
  controlInfo:
    bkinfo:
    dissinfo:
    jinfo:
      jid:
        11795549
        B3KT
      jtl: Clinical Medicine Insights: Oncology
      issn: 11795549
      maglogo: Y
    pubinfo:
      dt: 7/7/2026
      vid: 20
      pid: 344
      pub: Sage Publications Inc.
      place: Thousand Oaks, California
    artinfo:
      ui:
        195176268
        195176268
        195176268
        10.1177/11795549261466835
        195176268
      ppf: 1
      ppct: 11
      formats:
        fmt:
          – @attributes:
              type: T
          – @attributes:
              type: P
      tig:
        atl: Integrative Analysis of Clinical Features and Cerebrospinal Fluid Immune Microenvironment in Leptomeningeal Metastasis From Non-small-cell Lung Cancer Patients.
      aug:
        au:
          Chen, Junjun
          Zhou, Qihao
          Yin, Yuan
          Qin, Zhiquan
          Chen, Yun
        affil: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
      sug:
        subj:
          Carcinoma, Non-Small-Cell Lung Physiopathology
          Meningeal Carcinomatosis Physiopathology
          Carcinoma, Non-Small-Cell Lung Immunology
          Meningeal Carcinomatosis Immunology
          Cerebrospinal Fluid Analysis
          T Lymphocytes Analysis
          Tumor Markers, Biological Analysis
          Disease Progression
          Disease Attributes
          Human
          Male
          Female
          Middle Age
          Aged
          Aged, 80 and Over
          China
          Cancer Patients
          Retrospective Design
          Medical Records
          Record Review
          Nonexperimental Studies
          Funding Source
          Chemiluminescent Measurements
          Cell Count
          Flow Cytometry
          Immunoassay
          Descriptive Statistics
          T-Tests
          Wilcoxon Rank Sum Test
          Kaplan-Meier Estimator
          Survival Analysis
          Data Analysis Software
          Overall Survival
          Serum Albumin
          Lactate Dehydrogenase
          Lactic Acid
          Blood Glucose
          Chlorides
          Lymphocytes
          Antigens, Surface
          Middle Aged: 45-64 years
          Aged: 65+ years
          Aged, 80 & over
          Male
          Female
      ab: Background: Leptomeningeal metastasis (LM) represents one of the most severe complications in advanced lung cancer, indicating a poor prognosis. However, the mechanisms underlying LM progression remain incompletely understood, and reliable biomarkers for monitoring disease progression and treatment response are lacking. Methods: This retrospective observational study was conducted at the Zhejiang Provincial People's Hospital. Cerebrospinal fluid (CSF) samples from 13 patients with non–small cell lung cancer (NSCLC) and LM were analyzed, including biochemical parameters, tumor markers, differential cell counts, and T-cell subsets assessed by flow cytometry. Results: The median overall survival (mOS) after LM diagnosis was 15 months. During LM progression, increased CSF levels of albumin, lactate dehydrogenase (LDH), lactic acid, and carcinoembryonic antigen (CEA) were observed, accompanied by decreased glucose, chloride, lymphocyte proportion, and CD8+ T-cell proportion. In some cases, lymphocyte percentages and CD8+ T-cell proportions increased during subsequent evaluations following treatment adjustment. Conclusions: These findings suggest that CSF biochemical and immune parameters may be associated with disease progression in LM. Dynamic changes in CD8+ T-cell proportions may also reflect alterations in the CSF immune microenvironment and could represent potential targets for future immunotherapeutic strategies.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
    refInfo:
    holdings:
      @attributes:
        islocal: N