Efficacy and Safety of Xuebijing Injection, an Herbal-Based Injection, in Patients with Sepsis: Evidence from Randomized Controlled Trials of 3007 Subjects.
Background: Xuebijing injection was approved for treating sepsis; however, the efficacy and safety of Xuebijing injection in population with sepsis need further evaluation. We aimed to evaluate the safety and efficacy of Xuebijing injection on sepsis. Materials and Methods: We searched for potential...
| Publicado en: | Journal of Integrative & Complementary Medicine Vol. 32; no. 7; pp. 611 - 619 |
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| Autores principales: | , , , , |
| Formato: | pictorial research systematic review tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Jul2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195176410&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195176410 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 27683605 MX2I jtl: Journal of Integrative & Complementary Medicine issn: 27683605 maglogo: N pubinfo: dt: Jul2026 vid: 32 iid: 7 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 195176410 195176410 195176410 10.1177/27683605251415490 195176410 ppf: 611 ppct: 8 formats: tig: atl: Efficacy and Safety of Xuebijing Injection, an Herbal-Based Injection, in Patients with Sepsis: Evidence from Randomized Controlled Trials of 3007 Subjects. aug: au: Cao, Gang Liu, Liang He, Xin Wang, Rui Liang, Bo affil: Department of Rehabilitation, Chongqing Mental Health Center, Chongqing, China. sug: subj: Sepsis Drug Therapy Medicine, Chinese Traditional Plant Extracts Administration and Dosage Plant Extracts Therapeutic Use Plant Extracts Pharmacodynamics Drugs, Chinese Herbal Therapeutic Use Drug Efficacy Patient Safety Human China Male Female Systematic Review PubMed Embase Cochrane Library Body Temperature Hospital Mortality Comorbidity Adverse Drug Event Checklists Male Female ab: Background: Xuebijing injection was approved for treating sepsis; however, the efficacy and safety of Xuebijing injection in population with sepsis need further evaluation. We aimed to evaluate the safety and efficacy of Xuebijing injection on sepsis. Materials and Methods: We searched for potential randomized controlled trials about Xuebijing injection and sepsis from six public databases. Primary outcomes included the 28-day mortality and mortality during treatment. Our secondary outcomes were body temperature, APACHE Ⅱ score, and adverse events or reactions. All data were synthesized by the meta package. Results: A total of 3007 patients (1551 patients receiving the conventional treatment combined with Xuebijing injection and 1456 patients receiving the conventional treatment only) were included. We found Xuebijing injection reduced the 28-day mortality (risk ratio = 0.69 [0.60–0.78], p < 0.0001), mortality during treatment (risk ratio = 0.74 [0.62–0.88], p = 0.0009), APACHE II score (mean difference = 3.91 [2.45–5.38], p < 0.0001), and body temperature (mean difference = 0.43 [0.31–0.55], p < 0.0001) without obvious adverse events (risk ratio = 0.91 [0.77–1.07], p = 0.2405). Conclusions: Xuebijing injection is effective and safe for treating sepsis. Additional methodologically sound trials with long-term mortality as an outcome measure could provide further insights into whether Xuebijing injection offers an enhanced therapeutic effect for sepsis. pubtype: Academic Journal doctype: pictorial research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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