Neurochemical Determinants of Febrile Seizure Susceptibility in Children.
Abstract: Purpose: This study aimed to assess and compare serum levels of sodium, calcium, and magnesium in febrile children with and without seizures, and to examine the neurochemical association between electrolyte imbalance and neuronal excitability. Materials and Methods: A prospective case–cont...
| Published in: | Journal of Pediatric Neurosciences Vol. 21; no. 2; pp. 146 - 152 |
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| Main Authors: | , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Wolters Kluwer India Pvt Ltd
Apr-Jun2026
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195188572&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195188572 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18171745 1KUH jtl: Journal of Pediatric Neurosciences issn: 18171745 maglogo: N pubinfo: dt: Apr-Jun2026 vid: 21 iid: 2 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 195188572 195188572 195188572 10.4103/jpn.jpn_134_25 195188572 ppf: 146 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Neurochemical Determinants of Febrile Seizure Susceptibility in Children. aug: au: Ahmad, Abid Baba, Obair Ahmad, Showkat Shahid, Misbah Baba, Ainain affil: Department of Pediatrics and Neonatology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu, India sug: subj: Convulsions, Febrile Risk Factors Neurotransmitters Adverse Effects Disease Susceptibility Sodium Blood Calcium Blood Magnesium Blood Fluid-Electrolyte Imbalance Neurons Risk Assessment Fever In Infancy and Childhood Human India Male Female Prospective Studies Case Control Studies Hospitals, Pediatric Infant Child, Preschool Blood Specimen Collection Descriptive Statistics Data Analysis Software T-Tests Chi Square Test Comparative Studies Respiratory Tract Infections Etiology Infant: 1-23 months Child, Preschool: 2-5 years Male Female ab: Abstract: Purpose: This study aimed to assess and compare serum levels of sodium, calcium, and magnesium in febrile children with and without seizures, and to examine the neurochemical association between electrolyte imbalance and neuronal excitability. Materials and Methods: A prospective case–control study was conducted over 1 year in the Department of Pediatrics, including 200 children aged 6 months to 5 years, 100 with febrile seizures (FSs) and 100 age- and sex-matched febrile controls. Serum sodium, calcium, and magnesium levels were analyzed using an automated biochemistry analyzer. Data were compared using the independent-sample t test (Statistical Package for the Social Sciences, version 20.0; P < 0.05 considered significant). Results: Children with FSs had significantly lower serum sodium (135.5 ± 4.03 mmol/L), calcium (8.54 ± 0.33 mg/dL), and magnesium (1.81 ± 0.20 mg/dL) levels than controls (140.4 ± 2.78, 9.25 ± 0.51, and 2.07 ± 0.19, respectively; P < 0.001 for all). Most cases were under 2 years of age, and upper respiratory infections were the predominant cause of fever. No significant inter-electrolyte correlations were observed. Conclusion: Altered ionic homeostasis may be associated with transient changes in cortical excitability during febrile illness. Electrolyte evaluation may be considered in selected cases, such as prolonged or recurrent seizures; however, larger prospective outcome-based studies are required before universal routine screening can be recommended. Future studies integrating electrophysiological and neuroimaging correlates are warranted to elucidate the neurochemical mechanisms underlying FSs. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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