Trajectories and timing of accelerated decline in specific memory domains preceding Alzheimer's disease.
Introduction: Memory impairment is a hallmark feature of Alzheimer's disease (AD) and may emerge years before clinical diagnosis. However, the temporal sequence and acceleration patterns of decline across specific memory domains during the preclinical stage remain incompletely understood. This study...
| Publicado en: | Frontiers in Aging Neuroscience pp. 1 - 12 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Frontiers Media S.A.
2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195277296&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195277296 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 2026 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 195277296 195277296 195277296 10.3389/fnagi.2026.1868433 195277296 ppf: 1 ppct: 11 formats: tig: atl: Trajectories and timing of accelerated decline in specific memory domains preceding Alzheimer's disease. aug: au: Long, Xianxian Rong, Meng Long, Shushu Wen, Shuqin Mo, Luhui Xu, Mingming Zhang, Zeyun Nie, Qinqi affil: Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China sug: subj: Alzheimer's Disease Complications Memory Disorders Risk Factors Memory Disorders Risk Factors Memory Delayed Onset Risk Assessment Human Male Female Middle Age Aged Aged, 80 and Over Prospective Studies Comparative Studies Descriptive Statistics Data Analysis Software Sociodemographic Factors Memory, Short Term Cognition Disorders Risk Factors Disease Progression Mild Cognitive Impairment Neuropsychological Tests Aging Funding Source Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Introduction: Memory impairment is a hallmark feature of Alzheimer's disease (AD) and may emerge years before clinical diagnosis. However, the temporal sequence and acceleration patterns of decline across specific memory domains during the preclinical stage remain incompletely understood. This study aimed to characterize the longitudinal dynamics of four distinct memory processes in individuals progressing to clinical AD, and to identify the temporal sequence of continually accelerated decline. Methods: We analyzed longitudinal data from 382 participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) who converted from cognitively normal or mild cognitive impairment to AD. Generalized additive mixed models (GAMMs) were employed to characterize the nonlinear trajectories of four Rey Auditory Verbal Learning Test (RAVLT) derived scores over time prior to AD diagnosis, adjusting for key demographics and genetic factors. The finite difference method was applied to identify time points of continually accelerated decline from the fitted curves. Sensitivity analyses additionally adjusted for stroke and emotional incontinence, replicating all steps. Results: Our analysis revealed distinct nonlinear progression patterns across memory domains. All trajectories significantly deviated from linearity (Edf > 1, p < 0.001). Learning memory demonstrated the earliest continually accelerated decline, beginning 8.5 years before AD onset. APOE-ε4 allele carriage exhibited a dose-dependent effect, significantly associated with RAVLT_learning (β = −0.389 for one allele, −0.530 for two alleles) and RAVLT_forgetting (β = −0.449 for one allele, −0.508 for two alleles), but not with RAVLT_immediate performance. Females exhibited better immediate memory function than males, which was positively associated with years of education. Conclusion: The decline in four memory tests among individuals with preclinical AD followed nonlinear trajectories, with learning memory exhibiting the earliest continuously accelerated decline. Higher education was associated with better immediate memory performance, while the APOE-ε4 genotype specifically exacerbated impairments in learning memory and retention loss. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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