Lifestyle, socioeconomic, and biological determinants of survival in nonagenarians and centenarians: a systematic review and meta-analysis.
Background and Objectives Identifying factors associated with survival beyond age 90 is essential for understanding healthy aging trajectories. This study sought to investigate the associations between biological, socioeconomic, and lifestyle factors and survival in individuals aged ≥90 years. Resea...
| Publicado en: | Gerontologist Vol. 66; no. 7; pp. 1 - 18 |
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| Autores principales: | , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Jul2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=195281417&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 195281417 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00169013 GET jtl: Gerontologist issn: 00169013 maglogo: N pubinfo: dt: Jul2026 vid: 66 iid: 7 pid: 622 pub: Oxford University Press / USA artinfo: ui: 195281417 10.1093/geront/gnag079 ppf: 1 ppct: 17 formats: tig: atl: Lifestyle, socioeconomic, and biological determinants of survival in nonagenarians and centenarians: a systematic review and meta-analysis. aug: au: Caballero, Óscar García-Hermoso, Antonio Hurtado-Almonacid, Juan Yáñez-Sepúlveda, Rodrigo López-Gil, José Francisco Ezzatvar, Yasmin affil: Department of Nursing, Universitat de València, Valencia, Spain Navarrabiomed, Hospital Universitario de Navarra, Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain eFidac Grupo de Investigación, Escuela de Educación Física. Pontificia Universidad Católica de Valparaíso, Chile Faculty Education and Social Sciences, Universidad Andres Bello, Viña del Mar, Chile School of Medicine, Universidad Espíritu Santo, Samborondón, EcuadorFaculty of Health Sciences, Universidad Autónoma de Chile, Temuco, Chile Department of Nursing, Lifestyle Factors with Impact on Ageing and Overall Health (LAH) Research Group, University of València, Valencia, SpainVicerrectoría de Investigación y Postgrado, Universidad de Los Lagos, Osorno, Chile su: Lifestyles Socioeconomic factors Sex distribution Temperance Liberty Longevity Cognition Activities of daily living Drug abstinence Medical information storage & retrieval systems Nonagenarians Meta-analysis Multivariate analysis Descriptive statistics Systematic reviews MEDLINE Confidence intervals Centenarians Grip strength sug: subj: Lifestyles Socioeconomic factors Sex distribution Temperance Liberty Longevity Cognition Activities of daily living Drug abstinence Medical information storage & retrieval systems Nonagenarians Meta-analysis Multivariate analysis Descriptive statistics Systematic reviews MEDLINE Confidence intervals Centenarians Grip strength keyword: 80 and over activities of daily living aged adult cognition copyrightHolder:The Gerontological Society of America copyrightYear:2026 educational status follow-up healthy aging https://dx.doi.org/10.1093/geront/gnag079 inLanguage:en life style longevity mortality publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/42090458/ sensitivity analysis smoking socioeconomic factors Survival 80 and over activities of daily living aged adult cognition copyrightHolder:The Gerontological Society of America copyrightYear:2026 educational status follow-up healthy aging https://dx.doi.org/10.1093/geront/gnag079 inLanguage:en life style longevity mortality publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/42090458/ sensitivity analysis smoking socioeconomic factors Survival ab: Background and Objectives Identifying factors associated with survival beyond age 90 is essential for understanding healthy aging trajectories. This study sought to investigate the associations between biological, socioeconomic, and lifestyle factors and survival in individuals aged ≥90 years. Research Design and Methods Systematic review with meta-analysis. Cohort studies reporting information on lifestyle, socioeconomic, and biological determinants of survival in individuals aged ≥90 years (nonagenarians, centenarians, and supercentenarians) were searched in the MEDLINE, EMBASE, and Web of Science databases up to June 2025. Random effects meta-analyses via the empirical Bayes method generated pooled hazard ratios (HRs). Meta-regression and sensitivity analyses were conducted. Results Twenty-three studies were included. Being a woman (HR = 0.83; 95% confidence interval [CI], 0.80–0.86), having normal cognition (HR = 0.55; 95% CI, 0.40–0.76), having activities of daily living (ADL) independence (HR = 0.69; 95% CI, 0.63–0.76), having high handgrip strength (HR = 0.69; 95% CI, 0.48–0.99), not smoking (HR = 0.83; 95% CI, 0.74–0.93), and alcohol abstinence (HR = 0.88; 95% CI, 0.78–0.99) were associated with lower mortality. Education level was not significantly associated with survival. Meta-regression revealed no modifying effect of age or follow-up length. Multivariate meta-analysis confirmed the independent contribution of each factor and ranked ADLs (p < .001), cognition (p < .001), and handgrip strength (p < .001) as the top three survival predictors. Discussion and Implications Survival in the oldest-old is closely linked to female sex, preserved cognitive and physical function, and healthy lifestyle choices. The consistent predictive value of ADLs, cognition, and handgrip strength highlights the relevance of modifiable factors for promoting longevity, even in advanced age. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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