Hypothalamic Inflammation as a Critical Link Between Metabolic Dysfunction and Impaired Endometrial Receptivity in Obese Polycystic Ovary Syndrome.

Obese polycystic ovary syndrome (PCOS) involves insulin resistance (IR) and impaired endometrial receptivity, potentially driven by hypothalamic inflammation. We investigated if inhibiting the hypothalamic Toll-like receptor 4 (TLR4)/IκB kinase β (IKKβ) pathway could ameliorate IR and improve endome...

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Bibliographic Details

Published in:	Physiological Research Vol. 75; no. 3; pp. 485 - 498
Main Authors:	SUN, Chang, HAN, Yapeng, PAN, Zimeng, LI, Jing, CHENG, Xianzhuo, SUN, Miao, WANG, Ying, KUANG, Hongying
Format:	Journal Article
Published:	Institute of Physiology, Academy of Sciences of the Czech Republic Jun2026
Online Access:	View this record in EBSCOhost