The Effects of Geranylgeraniol Supplementation on Testosterone in Middle-Aged Healthy Adults: An 18-Week, Single-Group Crossover Placebo-Controlled Trial.
Background: Geranylgeraniol (GG) is a naturally occurring isoprenoid that is involved in steroid hormone synthesis, the endogenous production of coenzyme Q10 (CoQ10), healthy muscle function, bone metabolism, and cellular energy production. Although preclinical research and a recent human study have...
| Publicado en: | Integrative Medicine: A Clinician's Journal Vol. 25; no. 2; pp. 12 - 20 |
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| Autores principales: | , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
InnoVisions Professional Media
Apr2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195323859&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195323859 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1546993X 1C2O jtl: Integrative Medicine: A Clinician's Journal issn: 1546993X maglogo: N pubinfo: dt: Apr2026 vid: 25 iid: 2 pid: 65582 pub: InnoVisions Professional Media place: Eagan, Minnesota artinfo: ui: 195323859 195323859 195323859 195323859 ppf: 12 ppct: 8 formats: fmt: @attributes: type: P tig: atl: The Effects of Geranylgeraniol Supplementation on Testosterone in Middle-Aged Healthy Adults: An 18-Week, Single-Group Crossover Placebo-Controlled Trial. aug: au: Jurgelewicz, Michael D'Adamo, Christopher R. Malaya, Christopher A. affil: Human Nutrition Institute, University of Bridgeport, CT, USA sug: subj: Hydrocarbons Therapeutic Use Hydrocarbons Pharmacodynamics Dietary Supplementation Testosterone Drug Effects Coenzyme Q Drug Effects Sexual Health Evaluation Treatment Outcomes Evaluation Human Male Female Middle Age Crossover Design Placebos Therapeutic Use Control Group Clinical Trials Patient Compliance Monitoring, Physiologic Self Report Blood Specimen Collection Liquid Chromatography-Mass Spectrometry Methods Clinical Assessment Tools Scales Paired T-Tests Repeated Measures Analysis of Variance Post Hoc Analysis Questionnaires Effect Size Data Analysis Software Funding Source Middle Aged: 45-64 years Male Female ab: Background: Geranylgeraniol (GG) is a naturally occurring isoprenoid that is involved in steroid hormone synthesis, the endogenous production of coenzyme Q10 (CoQ10), healthy muscle function, bone metabolism, and cellular energy production. Although preclinical research and a recent human study have indicated a potential role for GG in modulating testosterone levels, its effects in middle-aged adults remain unclear. Aim: This study aimed to assess the effects of GG supplementation on testosterone status, coenzyme Q10 concentrations, and validated questionnaires of overall and sexual health in middle-aged healthy adults. Method: This 18-week, single-group, crossover, placebo-controlled trial involved participants aged 40 to 65 years. The intervention consisted of 8 weeks of placebo followed by a 2-week washout and 8 weeks of GG supplementation (300 mg/day). Outcomes were assessed at baseline, Week 8 (after blinded placebo), Week 10 (post-washout), and Week 18 (after blinded intervention). Results: Thirty-four participants completed the study. No significant changes were observed in total testosterone, free testosterone, or sex hormone binding globulin (all P > .05) in the full study sample or within the female subgroup. In the subgroup of men with lower baseline testosterone (<600 ng/dL, n = 8), total testosterone increased significantly following GG supplementation (mean difference = 28.44 ng/dL, 95% CI: 7.45--49.43, P = .015), with a large effect size (Cohen's d = 1.13), indicating a meaningful physiological response. Serum CoQ10 declined significantly during placebo (mean difference = -0.10 µg/mL, P = .03) but remained stable during GG supplementation (P = .9), suggesting a potential maintenance effect. Conclusion: These results highlight GG as a promising natural strategy to support endogenous testosterone production and CoQ10 homeostasis in age-related declines. Further investigation in larger, targeted populations such as men with late-onset hypogonadism or individuals on statin therapy is warranted. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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