Synthesis and structure–activity relationship of β-carboline derivatives with antifungal activity.
To search for and screen out effective antifungal lead compounds applicable to agriculture, a total of 21 tetrahydro-β-carboline derivatives were designed, synthesised, and evaluated for their antifungal activity. Based on biological studies, numerous compounds demonstrate notable antifungal propert...
| Publicado en: | Natural Product Research Vol. 40; no. 14; pp. 4108 - 4117 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jul2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195344245&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195344245 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: Jul2026 vid: 40 iid: 14 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 195344245 185119398 10.1080/14786419.2025.2502853 195344245 ppf: 4108 ppct: 9 formats: tig: atl: Synthesis and structure–activity relationship of β-carboline derivatives with antifungal activity. aug: au: Gao, Jie Li, Xiaohan Liu, Xinye Mei, Zhiyang Dan, Mingxia Zhan, Wei Zheng, Shaojun Zhu, Rui affil: School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, China sug: ab: To search for and screen out effective antifungal lead compounds applicable to agriculture, a total of 21 tetrahydro-β-carboline derivatives were designed, synthesised, and evaluated for their antifungal activity. Based on biological studies, numerous compounds demonstrate notable antifungal properties in vitro. Specifically, compounds a6 and a20 showed higher efficacy against Sclerotinia sclerotiorum compared to carbendazim, with EC50 values of 16.43 mg/L and 12.72 mg/L, respectively. Additionally, compound a16 exhibited exceptional antifungal activity against both S. sclerotiorum and Botrytis cinerea, achieving identical EC50 values of 12.71 mg/L for both pathogens. The results of this study will give reference for the additional design and structural optimisation of β-carboalkaloids as possible agrochemical lead compounds for plant disease control. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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