| Sumario: | Background: Breast cancer is a heterogeneous disease in which hormone receptor and HER2/neu expression patterns are closely associated with tumor histologic grade, prognosis, and treatment response. Objective: To investigate the correlation of hormone receptors and HER-2/Neu status with histologic grades of invasive ductal carcinoma of the breast. Design: A facility-based retrospective cross-sectional study. Methods: A facility-based retrospective cross-sectional study was conducted. Clinical and socio-demographic data were retrieved from medical records. Histopathological and immunohistochemical analysis were done according to standard procedures. Statistical analyses were performed using IBM SPSS version 25. Spearman's rank correlation coefficient was determined to assess the association between the histological grades, the receptors and the HER-2/Neu status. p -values less than 0.05 are considered as statistically significant. Result: One hundred forty BC cases were included in this study. The mean age of study subjects was 47. The most frequent age group was distributed within 36 to 45 years, with 49 cases (35%). Most (N=61, 43.6%) cases were identified to be grade II, followed by grade I (N=47, (33.6%) and grade III (22.9%, N=32). Majority of the BC tissues showed high expression of ER (N=103, 73.6%) and PR (N=68, 48.6%) and HER2 (N=31, 22.1%). Some of ER+ cases (N=43, 41.2%) were observed to be histological grade 1 whereas 43.7% (N=45) ER+ cases were identified to be histological grade II. The remaining 15% (N=12) were histological grade III. There were 21 cases which were categorized as triple negative breast cancer (TNBC), representing 15% of all the cases studied. Spearman's rank correlation analysis demonstrated a significant inverse association between histologic grade and ER and PR positivity (p <0.001), indicating that higher-grade tumors were less likely to express the receptors. Conclusion: The status of hormone receptors and HER-2/Neu in BC is similar to previous reports. An inverse correlation between histological grade and hormone receptor status is reported. Thus, more attention is needed from the health care authorities to improve the diagnostic capacity of pathology laboratories by widely availing access to immunohistochemistry services.
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