Infliximab-Responsive Severe Ulcerative Colitis With Pyoderma Gangrenosum After IL-6 and IGF-1 Blockade.
Interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) are involved in immune regulation and tissue repair, but their combined effects on gastrointestinal mucosa remain unclear. We report a case of new-onset ulcerative colitis with pyoderma gangrenosum after sequential IL-6 and IGF-1 receptor...
| Publicado en: | ACG Case Reports Journal Vol. 13; no. 6; pp. 1 - 5 |
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| Autores principales: | , , , , , , , , , |
| Formato: | case study pictorial Journal Article |
| Publicado: |
American College of Gastroenterology
Jun2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195387110&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195387110 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23263253 HJC2 jtl: ACG Case Reports Journal issn: 23263253 maglogo: N pubinfo: dt: Jun2026 vid: 13 iid: 6 pid: 94678 pub: American College of Gastroenterology place: Bethesda, Maryland artinfo: ui: 195387110 195387110 195387110 10.14309/crj.0000000000002203 195387110 ppf: 1 ppct: 4 formats: tig: atl: Infliximab-Responsive Severe Ulcerative Colitis With Pyoderma Gangrenosum After IL-6 and IGF-1 Blockade. aug: au: Onishi, Shinobu Otagiri, Shinsuke Shinkai, Akihiro Watanabe, Mika Tanaka, Sho Fujihata, Kenta Aoyama, Keiya Inoue, Ayano Katsurada, Takehiko Sakamoto, Naoya affil: School of Medicine, Hokkaido University, Sapporo, Japan sug: subj: Colitis, Ulcerative Diagnosis Colitis, Ulcerative Drug Therapy Colitis, Ulcerative Chemically Induced Pyoderma Gangrenosum Diagnosis Pyoderma Gangrenosum Drug Therapy Pyoderma Gangrenosum Chemically Induced Infliximab Therapeutic Use Tumor Necrosis Factor Female Middle Age Diarrhea Etiology Gastrointestinal Hemorrhage Etiology Colonoscopy Biopsy Tomography, X-Ray Computed Arthritis, Rheumatoid Graves' Ophthalmopathy Tocilizumab Prednisolone Treatment Outcomes Wound Healing Interleukins Somatomedins Middle Aged: 45-64 years Female ab: Interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) are involved in immune regulation and tissue repair, but their combined effects on gastrointestinal mucosa remain unclear. We report a case of new-onset ulcerative colitis with pyoderma gangrenosum after sequential IL-6 and IGF-1 receptor inhibition. The patient developed severe ulcerative colitis and pyoderma gangrenosum refractory to corticosteroids but showed rapid improvement after infliximab therapy, with endoscopic evidence of mucosal improvement. This case highlights a potential role for tumor necrosis factor-a (TNF-a) blockade in reversing severe immune dysregulation induced by IL-6 and IGF-1 inhibition. pubtype: Academic Journal doctype: case study pictorial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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