Primary Cutaneous Cryptococcosis in Immunocompetent Patients: Recognition and Management.
Primary cutaneous cryptococcosis (PCC) is a rare, localized fungal infection caused by Cryptococcus species, typically following direct inoculation of the yeast into the skin in immunocompetent individuals. Unlike disseminated cryptococcosis, which is more common in immunocompromised hosts, PCC rema...
| Publicado en: | American Journal of Clinical Dermatology Vol. 27; no. 4; pp. 779 - 789 |
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| Autores principales: | , , |
| Formato: | diagnostic images pictorial review tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195411102&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195411102 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11750561 C4Q jtl: American Journal of Clinical Dermatology issn: 11750561 maglogo: N pubinfo: dt: Jul2026 vid: 27 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 195411102 194276375 195411102 195411102 10.1007/s40257-026-01045-y 195411102 ppf: 779 ppct: 10 formats: tig: atl: Primary Cutaneous Cryptococcosis in Immunocompetent Patients: Recognition and Management. aug: au: Almatroud, Lanah Bayrak, Busra Yaprak Khachemoune, Amor affil: https://ror.org/05hs6h993 Michigan State University College of Human Medicine, East Lansing, MI, USA sug: subj: Immunocompetence Cryptococcosis Dermatomycoses Cryptococcus Cryptococcosis Diagnosis Cryptococcosis Epidemiology Cryptococcosis Symptoms Cryptococcosis Therapy Cryptococcosis Drug Therapy Diagnosis, Differential Administration, Oral Fluconazole Therapeutic Use Cryptococcosis Microbiology Environmental Exposure Occupational Exposure Microscopy Staining and Labeling Serologic Tests Molecular Diagnostic Techniques Polymerase Chain Reaction Radiography, Thoracic Blood Culture Spinal Puncture Tomography, X-Ray Computed ab: Primary cutaneous cryptococcosis (PCC) is a rare, localized fungal infection caused by Cryptococcus species, typically following direct inoculation of the yeast into the skin in immunocompetent individuals. Unlike disseminated cryptococcosis, which is more common in immunocompromised hosts, PCC remains confined to the skin and often arises after minor trauma or environmental exposure. Although traditionally associated with Cryptococcus neoformans (C. neoformans), Cryptococcus gattii (C. gattii) is also increasingly recognized in immunocompetent hosts. Dermatologists are crucial in the early identification of PCC, as its clinical presentation can resemble other dermatologic conditions such as bacterial cellulitis, pyoderma gangrenosum, or atypical mycobacterial infections. This review provides a comprehensive overview of the epidemiology, clinical features, diagnostic methods, and management strategies for PCC. It emphasizes the importance of differentiating PCC from disseminated cryptococcosis and other mimicking conditions. Treatment with oral azoles, such as fluconazole, is typically effective, with a favorable prognosis for most immunocompetent patients. The review also includes practical diagnostic algorithms to assist clinicians in the accurate and timely management of PCC, ultimately improving patient outcomes and reducing unnecessary interventions. pubtype: Academic Journal doctype: diagnostic images pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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