Default mode network hub disruption links problematic use of the Internet to brain network disorganization.
Problematic Use of the Internet (PUI) has been associated with functional alterations in the default mode network (DMN), which contains critical hubs in the entire brain network. Previous studies have predicted that hub disruption leads to widespread network alterations; however, whether DMN functio...
| Publicado en: | Comprehensive Psychiatry Vol. 149 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jul2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195467103&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195467103 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0010440X L9O jtl: Comprehensive Psychiatry issn: 0010440X maglogo: N pubinfo: dt: Jul2026 vid: 149 pid: 82545 pub: Elsevier B.V. place: Philadelphia, Pennsylvania artinfo: ui: 195467103 195467103 195467103 10.1016/j.comppsych.2026.152725 195467103 ppct: 1 formats: tig: atl: Default mode network hub disruption links problematic use of the Internet to brain network disorganization. aug: au: Takao, Nagara Oishi, Naoya Dai, Qi Yao, Lichang Yoshimura, Sayaka Shibata, Mami Aki, Morio Akahori, Saki Spantios, Michael Murai, Toshiya Fujiwara, Hironobu affil: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto 6068507, Japan sug: subj: Default Mode Network Brain Functional Connectivity Internet Addiction Human Male Female Adult Middle Age Aged Mediation Analysis Neuroradiography Magnetic Resonance Imaging Neural Networks (Computer) Descriptive Statistics Scales Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Problematic Use of the Internet (PUI) has been associated with functional alterations in the default mode network (DMN), which contains critical hubs in the entire brain network. Previous studies have predicted that hub disruption leads to widespread network alterations; however, whether DMN functional connectivity mediates the relationship between PUI and global network topology remains unclear. This study examined whether DMN connectivity mediates PUI-related brain network topology. Resting-state functional magnetic resonance imaging data were collected from 190 healthy participants aged 20–69 years. DMN functional connectivity was assessed using region of interest (ROI)-to-ROI analyses with the Generalized Problematic Internet Use Scale-2 (GPIUS-2) as the primary predictor, controlling for age, sex, and mean framewise displacement. Graph-theoretical analyses quantified whole-brain network properties, including the clustering coefficient (Cp), shortest path length (Lp), global efficiency (Eg), and local efficiency (Eloc). Mediation analyses were performed to determine whether DMN functional connectivity mediates the relationship between GPIUS-2 and each metric. The functional connectivity values of all 17 DMN cluster pairs showed negative partial correlations with PUI severity (p -FDR < 0.05). Mean DMN connectivity strongly predicted global network topology (|ρ| = 0.36–0.41, all p -FDR < 1 × 10−6). Mediation analyses revealed that DMN functional connectivity substantially mediated the relationship between PUI severity and each metric (indirect effects: all p -FDR < 0.001; all direct effects p > 0.49). Reduced DMN connectivity was associated with decreased Cp and Eloc, increased Eg, and decreased Lp, indicating a deviation from optimal small-world organization. DMN hub connectivity serves as a critical neurobiological pathway through which the PUI influences the whole-brain network organization. • DMN functional connectivity decreases with greater problematic use of the Internet. • DMN hub connectivity predicts whole-brain network topology. • DMN connectivity mediates the relationship between PUI and network topology. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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