Targeting Ferroptosis: Effects and Mechanisms of Action of Berberine.
Ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, plays a critical role in various diseases. Berberine, a bioactive compound from plants such as Coptis chinensis, tree turmeric, and barberry, exhibits bidirectional regulation of ferroptosis, but its syst...
| Publicado en: | American Journal of Chinese Medicine Vol. 54; no. 5; pp. 1475 - 1498 |
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| Autores principales: | , , , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
World Scientific Publishing Company
2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195499188&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195499188 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0192415X DYP jtl: American Journal of Chinese Medicine issn: 0192415X maglogo: N pubinfo: dt: 2026 vid: 54 iid: 5 pid: 2051 pub: World Scientific Publishing Company place: Hackensack, New Jersey artinfo: ui: 195499188 195107503 195499188 195499188 10.1142/S0192415X26500540 195499188 ppf: 1475 ppct: 23 formats: tig: atl: Targeting Ferroptosis: Effects and Mechanisms of Action of Berberine. aug: au: Cheng, Ting Xi, Hu Hao, Wenjie Yang, Yue Qian, Nannan Yang, Wenming affil: The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China sug: subj: Ferroptosis Drug Effects Phytochemicals Alkaloids Pharmacodynamics Signal Transduction Drug Effects Alkaloids Therapeutic Use Alkaloids Pharmacokinetics Iron Metabolism Homeostasis Drug Effects Lipid Peroxidation Drug Effects Antioxidants Drug Effects Cysteine Drug Effects Glutathione Drug Effects Glutathione Peroxidase Drug Effects Mitochondria Drug Effects NF-E2-Related Factor 2 Drug Effects AMP-Activated Protein Kinases Drug Effects Transferases Drug Effects Phosphotransferases Drug Effects Phosphoproteins Drug Effects Cardiovascular Diseases Prevention and Control Metabolic Diseases Prevention and Control Nervous System Diseases Prevention and Control Nanoparticle Drug Delivery System Molecular Structure Biological Availability Drug Efficacy Patient Safety Nanostructures Reactive Oxygen Species Drug Effects Neoplasms Prevention and Control Fibrosis Prevention and Control Alkaloids Administration and Dosage ab: Ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, plays a critical role in various diseases. Berberine, a bioactive compound from plants such as Coptis chinensis, tree turmeric, and barberry, exhibits bidirectional regulation of ferroptosis, but its systemic mechanisms remain unclear. This review summarizes berberine's effects through multiple signaling pathways, emphasizing context-dependent mechanisms, tissue-specific accumulation, and therapeutic potential. Relevant literature was retrieved from PubMed, Web of Science, CNKI, and ScienceDirect. Berberine modulates ferroptosis via iron homeostasis, lipid peroxidation, the System Xc−/GSH/GPX4 anti-oxidant system, and mitochondrial function, involving NRF2, p53, AMPK, PI3K/Akt, and MAPK pathways. It promotes ferroptosis in tumors and fibrotic diseases but inhibits it in cardiovascular, metabolic, and neurological disorders, alleviating tissue damage. Nano-delivery systems and structural optimization enhance bioavailability and targeting, demonstrating therapeutic efficacy and biosafety. Berberine's multi-target, bidirectional regulation shows promising clinical potential, warranting further mechanistic and delivery-focused studies. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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