Hippocampal formation–cortical high-fidelity memory networks in healthy older adults during the mnemonic discrimination task.
Introduction: Fidelity of detailed information retrieved from long-term memory (LTM) declines in aging due to changes affecting learning and remembering processes. Such behavioral deficits correspond with functional alterations in the hippocampal formation. However, it is unclear whether age-related...
| Publicado en: | Frontiers in Aging Neuroscience pp. 1 - 12 |
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| Autores principales: | , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Frontiers Media S.A.
2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195552000&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195552000 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 2026 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 195552000 195552000 195552000 10.3389/fnagi.2026.1788092 195552000 ppf: 1 ppct: 11 formats: tig: atl: Hippocampal formation–cortical high-fidelity memory networks in healthy older adults during the mnemonic discrimination task. aug: au: Chen, Joseph C. C. Gazzaley, Adam Wais, Peter E. affil: Department of Neurology, Neuroscape, University of California, San Francisco, CA, United States sug: subj: Hippocampus Physiology Task Performance and Analysis Cerebral Cortex Memory Temporal Lobe Brain Mapping Human Aged Functional Connectivity Male Female Magnetic Resonance Imaging Funding Source Aged: 65+ years Male Female ab: Introduction: Fidelity of detailed information retrieved from long-term memory (LTM) declines in aging due to changes affecting learning and remembering processes. Such behavioral deficits correspond with functional alterations in the hippocampal formation. However, it is unclear whether age-related decline in high-fidelity retrieval alters functional connections between hippocampal and cortical regions. Methods: Twenty-two cognitively intact older adults (69.4 ± 4.4 years) completed mnemonic discrimination tasks during fMRI indicating, whether previously encoded targets, lures, or novel objects were old or new. Results: Participants' high-fidelity memory, measured by the lure discrimination index (the proportion of "new" responses to lures minus the proportion of "old" responses to novel objects), was 0.45 ± 0.04 – lower than previously reported scores in young adults. High-fidelity LTM in older adults engaged a hippocampal formation region in the left entorhinal cortex with trial-wise beta-series connections to the right angular gyrus and the left precuneus. Discussion: Taken together, we characterize the distribution of medial temporal lobe (MTL)-cortical networks in older adults that underlies high-fidelity memory. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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