Low‐Level Alcohol Consumption in Children 11–12 Years Old Is Linked to Neural Substrates Involved in Reward Processing and Inhibitory Control: Results From a Brain‐Wide Association Study.
Background: We comprehensively examined the cross‐sectional and prospective structural (i.e., cortical volume and subcortical volume) and functional (i.e., activation during the Monetary Incentive Delay task and the emotional N‐back task) neural correlates of alcohol sipping in early adolescence acr...
| Publicado en: | Alcohol, Clinical & Experimental Research Vol. 50; no. 7; pp. 1 - 15 |
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| Autores principales: | , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jul2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195625297&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195625297 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 29937175 NACB jtl: Alcohol, Clinical & Experimental Research issn: 29937175 maglogo: N pubinfo: dt: Jul2026 vid: 50 iid: 7 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 195625297 195625297 195625297 10.1111/acer.70370 195625297 ppf: 1 ppct: 14 formats: tig: atl: Low‐Level Alcohol Consumption in Children 11–12 Years Old Is Linked to Neural Substrates Involved in Reward Processing and Inhibitory Control: Results From a Brain‐Wide Association Study. aug: au: Jackson, Isabella F. Meyer, Francisco A. C. Sullivan, Ryan M. Watts, Ashley L. affil: Department of Psychological Sciences, Vanderbilt University, Nashville Tennessee,, USA sug: subj: Neurons Physiology Reward Self Regulation Brain Physiology Alcohol Drinking In Infancy and Childhood Child Behavior Task Performance and Analysis In Infancy and Childhood Human Male Female Child United States Cross Sectional Studies Cell Nucleus Funding Source Magnetic Resonance Imaging Prospective Studies Neuropsychological Tests Neuroradiography Descriptive Statistics Data Analysis Software Child: 6-12 years Male Female ab: Background: We comprehensively examined the cross‐sectional and prospective structural (i.e., cortical volume and subcortical volume) and functional (i.e., activation during the Monetary Incentive Delay task and the emotional N‐back task) neural correlates of alcohol sipping in early adolescence across two waves of data from the Adolescent Brain Cognitive Development (ABCD) Study (baseline: ages 9–10, n = 7555; 2‐year follow‐up: ages 11–12, n = 5892). Methods: Generalized linear mixed models examined individual brain regions of interests' ability to predict alcohol sipping. Results: At the 2‐year follow‐up, sipping was associated with activation during the MID large reward versus neutral contrast in 12 regions (e.g., nucleus accumbens), and activation during the MID large loss versus neutral contrast in 13 regions (e.g., insula). Conclusions: These findings aligned with existing literature on alcohol consumption, with neural regions involved in reward and inhibitory control being associated with alcohol sipping. Given that the findings from year 2 mirror several well‐established neural correlates of alcohol use and alcohol use disorder in adults, alcohol sipping may be an important phenotype for predicting future alcohol involvement. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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