Investigating the effect of botox on the secondary skin defect healing in diabetic rats.
Background Delayed wound healing is a serious complication of diabetes mellitus, leading to chronic ulcers, infection, and prolonged recovery. Effective therapies are needed to improve both speed and quality of repair in diabetic conditions. Hypothesis/Aim This study evaluated whether botulinum toxi...
| Publicado en: | Journal of Wound Management Vol. 27; no. 2; pp. 1 - 7 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Cambridge Publishing
Jul2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195659397&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195659397 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 27885771 MZEQ jtl: Journal of Wound Management issn: 27885771 maglogo: N pubinfo: dt: Jul2026 vid: 27 iid: 2 pid: 66266 pub: Cambridge Publishing artinfo: ui: 195659397 10.35279/jowm2026.27.02.10 195659397 ppf: 1 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Investigating the effect of botox on the secondary skin defect healing in diabetic rats. aug: au: Sabzloun, Zohre Ronagh, Ali Tabatabaei, Seyed Reza Fatemi Rezaie, Anahita affil: Department of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran sug: ab: Background Delayed wound healing is a serious complication of diabetes mellitus, leading to chronic ulcers, infection, and prolonged recovery. Effective therapies are needed to improve both speed and quality of repair in diabetic conditions. Hypothesis/Aim This study evaluated whether botulinum toxin A (BTX-A) enhances healing of full-thickness skin wounds in diabetic rats. Methods In this randomised controlled study, 24 male Wistar rats were rendered diabetic with streptozotocin and assigned to two groups (n=12 each). A 20×20 mm dorsal full-thickness skin wound was created in each rat. The treatment group received 5 IU BTX-A injected intradermally around the wound; controls received saline. Wound closure was assessed on days 0, 7, 14, and 21. Histological evaluation of angiogenesis, fibroblast proliferation, collagen deposition and inflammatory infiltration was performed on days 7 and 14. Data were analysed using Prism software with significance set at P<0.05. Results/Findings By day 7, wound closure was greater in the BTX-A group (40%) compared with controls (25%). Histology showed enhanced angiogenesis, higher fibroblast counts, increased collagen content, and reduced inflammatory infiltration in the treated group. By day 21, wound healing reached 95% in the BTX-A group versus 81% in controls. No adverse effects or toxicity were observed. Conclusions BTX-A accelerated wound closure and improved tissue repair in diabetic rats. Implications for clinical practice BTX-A may offer a novel adjunctive therapy for chronic diabetic wounds, but further preclinical and clinical trials are required to confirm safety and efficacy. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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