Posterior segment alterations in keratoconus patients: an updated comprehensive review.
Keratoconus (KC) has traditionally been classified as a progressive anterior segment disorder, primarily affecting the cornea. However, emerging evidence from advanced imaging modalities—such as optical coherence tomography (OCT), OCT angiography, and enhanced depth imaging (EDI-OCT)—has revealed a...
| Published in: | Therapeutic Advances in Ophthalmology Vol. 18; pp. 1 - 18 |
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| Main Authors: | , , , , , , |
| Format: | review tables/charts Journal Article |
| Published: |
Sage Publications Inc.
7/29/2026
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195763957&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195763957 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 25158414 LAW0 jtl: Therapeutic Advances in Ophthalmology issn: 25158414 maglogo: Y pubinfo: dt: 7/29/2026 vid: 18 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 195763957 195763957 195763957 10.1177/25158414261462809 195763957 ppf: 1 ppct: 17 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Posterior segment alterations in keratoconus patients: an updated comprehensive review. aug: au: Mohmmed, Marrwan Hisham Ambrósio Jr, Renato Jadidi, Khosrow Hashemian, Hesam Narooie-Noori, Foroozan Naroo, Shehzad A. Khorrami-Nejad, Masoud affil: Data curation, Department of Optometry, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran sug: subj: Keratoconus Pathology Vitreous Body Pathology Retina Pathology Uvea Pathology Optic Nerve Pathology Blood Vessels Pathology Vitreous Body Blood Supply Retina Blood Supply Uvea Blood Supply Disease Progression Keratoconus Prognosis Keratoconus Therapy Individualized Medicine Eye Radiography Keratoconus Etiology Research, Medical Tomography, Optical Coherence Tomography, X-Ray Computed Keratoconus Risk Factors Age Factors ab: Keratoconus (KC) has traditionally been classified as a progressive anterior segment disorder, primarily affecting the cornea. However, emerging evidence from advanced imaging modalities—such as optical coherence tomography (OCT), OCT angiography, and enhanced depth imaging (EDI-OCT)—has revealed a broader spectrum of ocular involvement, including significant alterations in the posterior segment. This narrative review explores the structural and vascular changes observed in the retina, choroid, macula, and optic nerve head in KC patients, drawing on findings from more than 40 peer-reviewed studies. Retinal thickening, particularly in the central and parafoveal regions, has been consistently reported, with some studies suggesting a correlation between retinal morphology and disease severity. Vascular density reductions, especially in the superficial capillary plexus and radial peripapillary capillaries, have also been documented, suggesting microvascular compromise potentially associated with KC progression. Choroidal thickness appears to be increased in both pediatric and adult populations, with some evidence linking these changes to disease stage and systemic factors such as atopy. Although findings on macular thickness are more variable, patterns of thickening in early disease and thinning in advanced stages have been observed. Alterations in optic nerve head morphology and retinal nerve fiber layer parameters have also been noted, particularly in advanced or post-surgical cases. Taken together, these posterior segment changes challenge the traditional anterior-centric view of KC and suggest a more systemic ocular remodeling process. Understanding these alterations may enhance disease staging, prognostication, and personalized management strategies. While current evidence supports the clinical relevance of posterior segment evaluation in KC, further longitudinal studies with standardized imaging protocols are needed to clarify causality, functional implications, and potential therapeutic targets. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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