Cover Image
QR Code

Association of Clinical Pharmacist Interventions With Outcomes in Severe Diabetic Foot Infections: A Retrospective Cohort Study.

Background: It is common for clinical pharmacists to participate in the management of antimicrobial therapy in many countries, but not all countries have clinical pharmacists participating in the antimicrobial treatment of patients with diabetic foot. Aim: To evaluate the effects of the involvement...

Full description

Published in:Journal of Clinical Pharmacy & Therapeutics Vol. 2026; pp. 1 - 11
Main Authors: Wu, Ping, Ni, Chunyan, Sun, Xuemei, Xu, Wendong, Chauhan, Anjali
Format: care plan research tables/charts Journal Article
Published: Wiley-Blackwell 7/27/2026
Online Access:View this record in EBSCOhost
fields @attributes:
  recordID: 1
pdfLink:
plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195792254&site=ehost-live
header:
  @attributes:
    shortDbName: ccm
    uiTerm: 195792254
    longDbName: CINAHL Complete
    uiTag: AN
  controlInfo:
    bkinfo:
    dissinfo:
    jinfo:
      jid:
        02694727
        EV4
      jtl: Journal of Clinical Pharmacy & Therapeutics
      issn: 02694727
      maglogo: Y
    pubinfo:
      dt: 7/27/2026
      vid: 2026
      pid: 480
      pub: Wiley-Blackwell
      place: Malden, Massachusetts
    artinfo:
      ui:
        195792254
        195792254
        195792254
        10.1155/jcpt/5279339
        195792254
      ppf: 1
      ppct: 10
      formats:
        fmt:
          – @attributes:
              type: T
          – @attributes:
              type: C
          – @attributes:
              type: P
      tig:
        atl: Association of Clinical Pharmacist Interventions With Outcomes in Severe Diabetic Foot Infections: A Retrospective Cohort Study.
      aug:
        au:
          Wu, Ping
          Ni, Chunyan
          Sun, Xuemei
          Xu, Wendong
          Chauhan, Anjali
        affil: Department of Pharmacology,, The Third Affiliated Hospital,, Soochow University,, Changzhou, Jiangsu, China, scu.edu.tw
      sug:
        subj:
          Pharmacists
          Treatment Outcomes
          Diabetic Foot Drug Therapy
          Severity of Illness
          Infection Control
          Professional Role
          Human
          Retrospective Design
          Prospective Studies
          Male
          Female
          Middle Age
          Aged
          Comparative Studies
          Descriptive Statistics
          Hospitalization
          Leukocytes
          C-Reactive Protein Blood
          Calcitonin Blood
          Antiinfective Agents Therapeutic Use
          Readmission
          Patient Discharge
          Data Analysis Software
          T-Tests
          Mann-Whitney U Test
          Chi Square Test
          Fisher's Exact Test
          Logistic Regression
          Linear Regression
          Funding Source
          Middle Aged: 45-64 years
          Aged: 65+ years
          Male
          Female
      ab: Background: It is common for clinical pharmacists to participate in the management of antimicrobial therapy in many countries, but not all countries have clinical pharmacists participating in the antimicrobial treatment of patients with diabetic foot. Aim: To evaluate the effects of the involvement of clinical pharmacists in the management of severe infection in patients with diabetic foot. Method: A total of 89 patients with severe diabetic foot infection were enrolled in this retrospective study from January 2020 to December 2024, and they were divided into the study group (SG, n = 44) and the control group (CG, n = 45). Patients in the SG received clinical pharmacist intervention during hospitalization, while those in the CG received only general services. The Student′s t‐test and the Mann–Whitney U test were used for intergroup comparison of continuous variables, while the Chi‐square test was adopted for categorical variables. Results: No significant differences were identified between the SG and CG with respect to their sociodemographic or infection characteristics. The median duration of fever was shorter in the SG (3.00 days) than in the CG (6.00 days). After 3 days of antimicrobial treatment, the SG showed significantly larger decreases in the WBC count, C‐reactive protein (CRP), and procalcitonin (PCT) than the CG (p < 0.05). The SG had a significantly higher prevalence of appropriate initial empirical antimicrobial therapy (93.18% vs. 48.89%, p = 0.001), fewer drug‐related complications (13.64% vs. 51.11%, p < 0.001), and a lower prevalence of readmission over the first 12 months following discharge (2.27% vs. 17.78%, p = 0.030). The prevalence of antimicrobial regimen adjustments of ≥ 2 was also lower in the SG group (9.10% vs. 35.56%, p = 0.004). There were no significant differences in the prevalence of amputation or the defined daily dose between the groups. Conclusion: The involvement of clinical pharmacists in the management of severe infection in patients with diabetic foot was associated with improved acute infection control and the alleviation of drug‐related problems associated with antimicrobial agents, thereby providing a valuable reference for antimicrobial therapy management in such patients.
      pubtype: Academic Journal
      doctype:
        care plan
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
    refInfo:
    holdings:
      @attributes:
        islocal: N