Correlation Between Ambulatory Blood Pressure Monitoring and Target Organ Damage in Children.
Highlights: What are the main findings? Elevated 24-h ambulatory systolic blood pressure was independently correlated with left ventricular hypertrophy; however, exploratory machine-learning models using ABPM parameters to assess comprehensive target organ damage risk showed limited discrimination....
| Publicado en: | Children Vol. 13; no. 7; pp. 955 - 968 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
MDPI
Jul2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195798392&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195798392 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 22279067 LW6K jtl: Children issn: 22279067 maglogo: N pubinfo: dt: Jul2026 vid: 13 iid: 7 pid: 97109 pub: MDPI artinfo: ui: 195798392 195798392 195798392 10.3390/children13070955 195798392 ppf: 955 ppct: 13 formats: tig: atl: Correlation Between Ambulatory Blood Pressure Monitoring and Target Organ Damage in Children. aug: au: Öztürk, Musa Bakırarar, Batuhan Özçakar, Zeynep Birsin Çakar, Nilgün Doğanay, Beyza Tutar, Ercan Yalçınkaya, Fatoş affil: Department of Pediatrics, Ankara University Faculty of Medicine, Ankara 06100, Türkiye sug: subj: Blood Pressure Monitoring, Ambulatory Hypertrophy, Left Ventricular Hypertension Retinal Diseases In Infancy and Childhood Human Turkiye Female Male Child Adolescence Retrospective Design Descriptive Statistics Data Analysis Software T-Tests Mann-Whitney U Test Chi Square Test Fisher's Exact Test ROC Curve Multivariate Analysis Logistic Regression Odds Ratio Confidence Intervals Random Forest Multilayer Perceptrons Machine Learning Body Mass Index Child: 6-12 years Adolescent: 13-18 years Female Male ab: Highlights: What are the main findings? Elevated 24-h ambulatory systolic blood pressure was independently correlated with left ventricular hypertrophy; however, exploratory machine-learning models using ABPM parameters to assess comprehensive target organ damage risk showed limited discrimination. No independent association was observed between ABPM metrics and hypertensive retinopathy. What are the implications of the main findings? ABPM-derived systolic parameters may support cardiovascular risk stratification and help identify children who need closer evaluation for target-organ damage. The proposed lower percentile thresholds and ABPM-based prediction models require prospective external validation before clinical implementation. Background: Ambulatory blood pressure monitoring (ABPM) offers a comprehensive assessment of mean blood pressure (BP), circadian patterns, and out-of-office hypertension phenotypes. We evaluated the association of ABPM parameters with left ventricular hypertrophy (LVH) and hypertensive retinopathy (HRP) in children with hypertension. Methods: This retrospective analysis included 269 children who underwent ABPM at a tertiary care facility. Multivariable logistic regression was used to evaluate associations between BP Z scores and target organ damage (TOD), adjusting for age, sex, and body mass index standard deviation score. Machine learning techniques (logistic regression, random forest, and multilayer perceptron) were also evaluated using 10-fold cross-validation across exploratory combinations of the 90th or 95th percentiles and BP-load thresholds of 25% or 50%. Results: LVH was detected in 45/247 patients (18%) and HRP was observed in 22/240 patients (9%). The 24 h systolic BP Z score was independently associated with LVH (adjusted OR 1.44; 95% CI 1.16–1.80; p = 0.001). Cohort-derived systolic Z-score thresholds for LVH were 1.31 for 24 h systolic BP and 1.47 for nighttime systolic BP, corresponding to approximately the 90.6th and 93rd percentiles, respectively. No variable evaluated was independently associated with retinopathy. Logistic regression using the 90th percentile/25% load dataset showed the highest performance among the evaluated classifiers, but discrimination was limited (ROC area 0.603; MCC 0.041). Conclusions: Higher ambulatory systolic BP was independently associated with LVH but not with clinically detected hypertensive retinopathy. ABPM values at or above the 90th percentile and a systolic load of ≥25% may help identify children at increased risk of TOD, although these thresholds remain exploratory and require prospective external validation. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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