| Sumario: | Simple Summary: The Canadian cancer care system is facing significant challenges due to a rising number of patients and a shortage of healthcare professionals. While many innovative solutions have been developed to improve care, they are often not shared or expanded across the entire country. This study reviewed over 30 successful innovations such as virtual care, at-home treatments, and the use of artificial intelligence to understand what makes them work. Analysis indicates that while these programs improve patient satisfaction and reduce hospital pressure, they are often held back by inconsistent funding and technology gaps. These findings provide a clear roadmap for health leaders and policymakers to adopt proven models of care more broadly. By identifying exactly what helps or hinders these changes, this work aims to ensure that high-quality, person-centred cancer care is available to everyone in Canada, regardless of where they live. The Canadian cancer care landscape faces rising cancer incidence, persistent inequities, and increasing system pressures. Led by the Canadian Association of Provincial Cancer Agencies (CAPCA), this scoping review applied an implementation science lens to evaluate the scalability of innovative cancer care models across Canada. Using a mixed-methods design, innovations were identified through a scoping review (n = 42), grey literature analysis (>50), a pan-Canadian survey (n = 72), and key informant interviews (n = 24). Guided by the Consolidated Framework for Implementation Research (CFIR), this review assessed feasibility, barriers, and facilitators influencing adoption and scale-up of identified innovations. Results revealed widespread adoption across various domains including virtual oncology, artificial intelligence (AI)-driven tools, and expansion of team-based care. At-home models, including home infusion, palliative care, and pharmacist-led chronic disease clinics, demonstrated improved access, patient satisfaction, and reduced hospital burden. CFIR mapping revealed cross-cutting facilitators including strong stakeholder engagement, structured training, and demonstrated patient benefits. However, persistent barriers include regulatory variability, funding instability, digital infrastructure gaps, and workforce capacity constraints. This paper highlights implemented innovations in cancer care and identifies strategic scaling opportunities needed to ensure all people living in Canada benefit from high-quality, person-centred equitable cancer care.
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