Prenatal Exposure to Ambient Particulate Matter and Autism Spectrum Disorder in Children, a Case Control Study in France.
A series of epidemiological studies conducted in the United States have consistently shown an increased risk of autism spectrum disorder (ASD) in children associated with pre- and postnatal exposure to ambient particulate matter (PM). In Europe, studies are scarce and results are inconsistent. We ai...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 56; no. 9; pp. 3713 - 3726 |
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| Autores principales: | , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195843181&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195843181 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Sep2026 vid: 56 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 195843181 183890904 195843181 195843181 10.1007/s10803-025-06795-y 195843181 ppf: 3713 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Prenatal Exposure to Ambient Particulate Matter and Autism Spectrum Disorder in Children, a Case Control Study in France. aug: au: Mortamais, Marion Ongono, Jeanne Sandrine Michelon, Cécile Hough, Ian Seyve, Emie Kloog, Itai Zaros, Cécile Charles, Marie-Aline Lepeule, Johanna Baghdadli, Amaria affil: https://ror.org/051escj72 Institute for Neurosciences of Montpellier (INM), University of Montpellier, Inserm, Montpellier, France sug: subj: Autism Spectrum Disorder Risk Factors Air Pollution Adverse Effects Particulate Matter Adverse Effects Prenatal Exposure Delayed Effects Risk Assessment Human Funding Source France Male Female Child Case Control Studies Descriptive Statistics Wilcoxon Rank Sum Test Logistic Regression Chi Square Test Odds Ratio Fisher's Exact Test Confidence Intervals Environmental Exposure Risk Factors Maternal Exposure Risk Factors Mental Disorders Diagnosed in Childhood Checklists Child: 6-12 years Male Female ab: A series of epidemiological studies conducted in the United States have consistently shown an increased risk of autism spectrum disorder (ASD) in children associated with pre- and postnatal exposure to ambient particulate matter (PM). In Europe, studies are scarce and results are inconsistent. We aimed to investigate the association between prenatal exposure to PM and the risk of ASD in France. ASD cases were participants from the ELENA cohort. Controls children from the ELFE cohort were matched by sex, year (± 2) and region of birth. Prenatal exposures to PM10 and to PM2.5 were estimated between 2008 and 2013 using innovative hybrid spatio-temporal models developed for France. Conditional logistic regression models adjusted for birth season, parent's age at the child birth and parental education level were run. We included 125 ASD cases and 500 controls. Prenatal PM2.5 and PM10 median (IQR) concentration estimates were respectively 16.3 (3.9) µg/m3 and 22.9 (6.6) µg/m3 in the whole sample. The conditional logistic regression models showed Odds Ratios (ORs) (Confidence Interval 95%) for ASD risk of 0.72 (0.52–1.01) and 0.84 (0.58–1.22) for an IQR increase in PM2.5 and PM10 prenatal levels, respectively. When restricting population of ASD cases to children born the same year of controls, ORs were 1.79 (0.80–4.01) and 2.23 (0.71–9.04), respectively. Our results did not show that prenatal exposures to PM2.5 and PM10 were associated with the risk of ASD in children in France. Trial Registration Number NCT02625116. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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