Overlapping premorbid frailty, multimorbidity and malnutrition and their associations with poor outcomes in patients with stroke.
Aim This study aimed to explore the prevalence of these overlapping premorbid geriatric conditions and examine the association between the number of these conditions and the risk of mortality and major cardiovascular events within 1 year after acute stroke. Methods In this single-centre prospective...
| Publicado en: | Age & Ageing Vol. 55; no. 7; pp. 1 - 12 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Jul2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=195867353&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 195867353 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jul2026 vid: 55 iid: 7 pid: 622 pub: Oxford University Press / USA artinfo: ui: 195867353 10.1093/ageing/afag198 ppf: 1 ppct: 11 formats: tig: atl: Overlapping premorbid frailty, multimorbidity and malnutrition and their associations with poor outcomes in patients with stroke. aug: au: Nozoe, Masafumi Inoue, Tatsuro Ogawa, Masato Ogino, Tomoyuki Okuda, Kazuki Yamamoto, Kenta Sato, Yoichi Abe, Takafumi Kimura, Yosuke Tanaka, Shu affil: Department of Physical Therapy, School of Rehabilitation, Hyogo Medical University, Kobe, JapanDepartment of Data Science, Hyogo Medical University, Nishinomiya, JapanHealth Promotional Physical Therapy for Stroke Survivors, Japanese Society of Neurological Physical Therapy, Tokyo, Japan Department of Physical Therapy, Niigata University of Health and Welfare, Niigata, Japan Faculty of Health Science, Osaka Health Science University, Osaka, Japan Department of Physical Therapy, School of Rehabilitation, Hyogo Medical University, Kobe, Japan Department of Rehabilitation, Konan Medical Center, Kobe, Japan Health Promotional Physical Therapy for Stroke Survivors, Japanese Society of Neurological Physical Therapy, Tokyo, JapanDepartment of Rehabilitation, Uonuma Kikan Hospital, Niigata, Japan Health Promotional Physical Therapy for Stroke Survivors, Japanese Society of Neurological Physical Therapy, Tokyo, JapanFaculty of Life Sciences, Department of Biomedical Engineering, Toyo University, Saitama, Japan Health Promotional Physical Therapy for Stroke Survivors, Japanese Society of Neurological Physical Therapy, Tokyo, JapanMajor of Physical Therapy, Department of Rehabilitation, School of Health Sciences, Tokyo University of Technology, Tokyo, Japan su: Japan Malnutrition Hypertension Chronic diseases Stroke Diabetes Disease risk factors Mortality risk factors Myocardial infarction Risk assessment NIH Stroke Scale Hyperlipidemia Research funding Frail elderly Major adverse cardiovascular events Nutritional assessment Kruskal-Wallis Test Heart failure Longitudinal method Chronic kidney failure Liver diseases Kaplan-Meier estimator Log-rank test Geriatric assessment Atrial fibrillation Obstructive lung diseases One-way analysis of variance Tumors Comorbidity Proportional hazards models Disease complications sug: subj: Malnutrition Hypertension Chronic diseases Stroke Diabetes Disease risk factors Japan Mortality risk factors Myocardial infarction Risk assessment NIH Stroke Scale Hyperlipidemia Research funding Frail elderly Major adverse cardiovascular events Nutritional assessment Kruskal-Wallis Test Heart failure Longitudinal method Chronic kidney failure Liver diseases Kaplan-Meier estimator Log-rank test Geriatric assessment Atrial fibrillation Obstructive lung diseases One-way analysis of variance Tumors Comorbidity Proportional hazards models Disease complications keyword: acute cerebrovascular accidents aged aging all-cause mortality cerebrovascular accident copyrightHolder:British Geriatrics Society copyrightYear:2026 frailty https://dx.doi.org/10.1093/ageing/afag198 inLanguage:en ischemic stroke malnutrition mortality multimorbidity older people premorbid publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/42391556/ acute cerebrovascular accidents aged aging all-cause mortality cerebrovascular accident copyrightHolder:British Geriatrics Society copyrightYear:2026 frailty https://dx.doi.org/10.1093/ageing/afag198 inLanguage:en ischemic stroke malnutrition mortality multimorbidity older people premorbid publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/42391556/ ab: Aim This study aimed to explore the prevalence of these overlapping premorbid geriatric conditions and examine the association between the number of these conditions and the risk of mortality and major cardiovascular events within 1 year after acute stroke. Methods In this single-centre prospective cohort study, consecutive stroke patients admitted between November 2020 and September 2024 were enrolled. Premorbid frailty was assessed using the 33-item Rockwood Frailty Index. Multimorbidity was defined as the presence of two or more chronic comorbidities other than stroke. Malnutrition was diagnosed according to the Global Leadership Initiative on Malnutrition criteria. Patients were categorised according to the number of overlapping conditions (NOCs), ranging from 0 to 3. The primary outcome was a composite of all-cause mortality and major adverse cardiovascular events within 1 year after admission. Cox proportional hazards regression models adjusted for potential confounders were used to estimate adjusted hazard ratios. Results Among 781 patients (mean age 77.9 ± 12.6 years; 390 [49.9%] female), 226 patients (28.9%) were NOC 0, 289 (37.0%) were NOC 1, 161 (20.6%) were NOC 2 and 105 (13.4%) were NOC 3. Compared with NOC 0, the adjusted hazard ratios for the composite outcome were 1.52 (95% CI 0.86–2.68) for NOC 1, 2.64 (95% CI 1.44–4.85) for NOC 2 and 5.20 (95% CI 2.77–9.73) for NOC 3. Conclusions One-third of patients with acute stroke had overlapping premorbid geriatric conditions. The NOCs was significantly associated with a composite event in a dose–response manner. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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