Frailty phenotype transitions and functional improvements during a supervised exercise trial in older people with HIV: results from the HEALTH Trial.
Background Frailty and sarcopenia contribute to functional decline in older people with HIV (PWH), yet intervention data remain limited. We evaluated changes in frailty phenotype status, sarcopenia-related outcomes and functional performance during a supervised exercise trial and assessed associatio...
| Publicado en: | Age & Ageing Vol. 55; no. 7; pp. 1 - 11 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Jul2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=195867354&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 195867354 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jul2026 vid: 55 iid: 7 pid: 622 pub: Oxford University Press / USA artinfo: ui: 195867354 10.1093/ageing/afag199 ppf: 1 ppct: 10 formats: tig: atl: Frailty phenotype transitions and functional improvements during a supervised exercise trial in older people with HIV: results from the HEALTH Trial. aug: au: Oliveira, Vitor H F Santos, Andre P dos Kulik, Grace L Davey, Christine Horvat Iriarte, Evelyn Jones, Raymond Wilson, Melissa P Khuu, Vincent Ghosh, Debashis Mawhinney, Samantha affil: School of Nursing, University of Washington, Seattle, WA, USA Department of Medicine, University of Colorado Anschutz, Aurora, CO, USA Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA College of Nursing, University of Colorado Anschutz, Aurora, CO, USA Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA Department of Biostatistics & Informatics, University of Colorado Anschutz, Aurora, CO, USA su: Supervision of employees Therapeutics Statistical models Secondary analysis Data analysis Research funding Frail elderly Exercise therapy High-intensity interval training Fatigue (Physiology) Logistic regression analysis HIV infections Treatment effectiveness Descriptive statistics Exercise intensity Resistance training Walking Log-rank test Geriatric assessment Confidence intervals Data analysis software Phenotypes Sarcopenia Physical activity sug: subj: Supervision of employees Therapeutics Statistical models Secondary analysis Data analysis Research funding Frail elderly Exercise therapy High-intensity interval training Fatigue (Physiology) Logistic regression analysis HIV infections Treatment effectiveness Descriptive statistics Exercise intensity Resistance training Walking Log-rank test Geriatric assessment Confidence intervals Data analysis software Phenotypes Sarcopenia Physical activity keyword: aged continuing copyrightHolder:British Geriatrics Society copyrightYear:2026 education exercise fatigue frail elderly frailty health healthy ageing high-intensity hiv hiv patients https://dx.doi.org/10.1093/ageing/afag199 inLanguage:en interval training medical muscle mass older people phenotype physical function publisher:Oxford University Press rehabilitation sameAs:https://pubmed.ncbi.nlm.nih.gov/42407092/ sarcopenia aged continuing copyrightHolder:British Geriatrics Society copyrightYear:2026 education exercise fatigue frail elderly frailty health healthy ageing high-intensity hiv hiv patients https://dx.doi.org/10.1093/ageing/afag199 inLanguage:en interval training medical muscle mass older people phenotype physical function publisher:Oxford University Press rehabilitation sameAs:https://pubmed.ncbi.nlm.nih.gov/42407092/ sarcopenia ab: Background Frailty and sarcopenia contribute to functional decline in older people with HIV (PWH), yet intervention data remain limited. We evaluated changes in frailty phenotype status, sarcopenia-related outcomes and functional performance during a supervised exercise trial and assessed associations between baseline frailty, study withdrawal and intervention response. Methods The High-Intensity Exercise to Attenuate Limitations and Train Habits in Older Adults with HIV (HEALTH) study randomised sedentary PWH aged ≥50 years to 16 weeks of supervised high-intensity interval training (HIIT) or continuous moderate exercise (CME), both combined with progressive resistance training. Frailty was assessed using Fried's phenotype; sarcopenia using current consensus definitions and exploratory HIV-specific cut-points. Functional outcomes included 400-m walk performance and fatigue. Results Of 118 participants (median age 58 years; 85% male), 94 completed the intervention. Among completers, pre-frailty/frailty status decreased from 48.9% to 30.9% (P < .01), largely reflecting improvements in exhaustion and low activity, with no significant differences between HIIT and CME. Sarcopenia prevalence was low at baseline and changed minimally across definitions. Participants with baseline pre-frailty/frailty were more likely to withdraw (P = .03), yet among retained participants demonstrated greater improvements in 400-m walk performance than non-frail participants (−7.1% [95%CI −8.7, −5.4] vs −4.6% [95% CI −6.3, −2.8]). Fatigue improved among participants with baseline pre-frailty/frailty (−3.3 points [95% CI −5.7, −0.9]) but not in non-frail participants (−1.0 points [95% CI −3.4, 1.4]). Conclusions During this supervised exercise trial, favourable frailty phenotype transitions and functional improvements were observed among older PWH, particularly in participants with baseline pre-frailty/frailty. Low sarcopenia prevalence limited conclusions regarding categorical sarcopenia outcomes. Strategies to improve retention among more vulnerable participants may enhance intervention reach and impact. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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