Does immediate orthostatic hypotension in adults have clinical implications for syncope and falls? An analysis of the Irish longitudinal study of ageing.
Background and Aims Orthostatic hypotension is a common cause of syncope and falls; however, it is unclear if the association differs by variant. One of the variants is immediate orthostatic hypotension (formerly initial), which may be of lesser clinical importance than other variants. The Irish Lon...
| Publicado en: | Age & Ageing Vol. 55; no. 7; pp. 1 - 9 |
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| Autores principales: | , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Jul2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=195867359&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 195867359 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jul2026 vid: 55 iid: 7 pid: 622 pub: Oxford University Press / USA artinfo: ui: 195867359 10.1093/ageing/afag204 ppf: 1 ppct: 8 formats: tig: atl: Does immediate orthostatic hypotension in adults have clinical implications for syncope and falls? An analysis of the Irish longitudinal study of ageing. aug: au: Reddin, Catriona Briggs, Robert Knight, Silvin P Kenny, Rose-Anne affil: Health Research Board Clinical Research Facility Galway, University of Galway, Galway H91 TK33, IrelandGalway University Hospitals, Newcastle Road Galway, Galway, Ireland Mercer's Institute for Successful Ageing, St James's Hospital, Dublin, Ireland Discipline of Medical Gerontology, The Irish Longitudinal Study on Ageing (TILDA) Trinity Central, University of Dublin Trinity College, 152-160 Pearse St, Dublin 2, Co Dublin D02 R590, Ireland Mercer's Institute for Successful Ageing, St James's Hospital, Dublin, IrelandDiscipline of Medical Gerontology, The Irish Longitudinal Study on Ageing (TILDA) Trinity Central, University of Dublin Trinity College, 152-160 Pearse St, Dublin 2, Co Dublin D02 R590, Ireland su: Disease risk factors Old age Risk assessment Statistical significance Research funding Syncope Multiple regression analysis Multivariate analysis Chi-squared test Mann Whitney U Test Descriptive statistics Longitudinal method Heart beat Orthostatic hypotension Ambulatory blood pressure monitoring Data analysis software Accidental falls Blood pressure measurement Postural balance Disease complications sug: subj: Disease risk factors Old age All Other Miscellaneous Ambulatory Health Care Services Risk assessment Statistical significance Research funding Syncope Multiple regression analysis Multivariate analysis Chi-squared test Mann Whitney U Test Descriptive statistics Longitudinal method Heart beat Orthostatic hypotension Ambulatory blood pressure monitoring Data analysis software Accidental falls Blood pressure measurement Postural balance Disease complications keyword: adult aging copyrightHolder:British Geriatrics Society copyrightYear:2026 falls https://dx.doi.org/10.1093/ageing/afag204 inLanguage:en older people orthostatic hypotension publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/42462204/ syncope adult aging copyrightHolder:British Geriatrics Society copyrightYear:2026 falls https://dx.doi.org/10.1093/ageing/afag204 inLanguage:en older people orthostatic hypotension publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/42462204/ syncope ab: Background and Aims Orthostatic hypotension is a common cause of syncope and falls; however, it is unclear if the association differs by variant. One of the variants is immediate orthostatic hypotension (formerly initial), which may be of lesser clinical importance than other variants. The Irish Longitudinal Study of Ageing offers a unique opportunity to evaluate the association of orthostatic hypotension variants with falls and syncope events in adults 50 years and older. Methods Blood pressure (BP) and heart rate were measured supine and standing using phasic blood pressure techniques. Initial OH was defined as a drop in systolic BP >40mmHg and/or diastolic BP >20 mm Hg at 10 seconds after standing, with recovery to within 20mmHg of baseline Systolic BP and 10 mmHg diastolic BP by 20 seconds. Orthostatic hypotension was defined as a persisting drop in systolic BP ≥20mmHg and/or drop in diastolic BP ≥10mmHg. The association of orthostatic hypotension variants with syncope and unexplained falls events (primary outcome) over 8 years follow up were evaluated using multivariable logistic regression models. Results 4,596 participants were included in this analysis; 953 (20.7%) met criteria for immediate orthostatic hypotension, 1,008 (22.0%) for orthostatic hypotension. Orthostatic hypotension, but not immediate orthostatic hypotension was associated with increased odds of syncope or unexplained falls (Orthostatic hypotension: OR 1.31; 95% CI, 1.04–1.66, Immediate orthostatic hypotension: OR 1.22; 95% CI, 0.93–1.57). Conclusion Immediate orthostatic hypotension is common, and not associated with unexplained falls or syncope. The terminology immediate orthostatic hypotension may be more appropriate. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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