Blood pressure polygenic score, cardiorespiratory fitness and odds of dementia: the HUNT Study.
High blood pressure (BP) is linked to an increased dementia risk. The role of sex and the impact of cardiorespiratory fitness (CRF) on the potential association between genetic predisposition to high blood pressure and dementia are less understood. Our aim was to investigate if there is an associati...
| Publicado en: | Age & Ageing Vol. 55; no. 7; pp. 1 - 10 |
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| Autores principales: | , , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Jul2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=195867369&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 195867369 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jul2026 vid: 55 iid: 7 pid: 622 pub: Oxford University Press / USA artinfo: ui: 195867369 10.1093/ageing/afag214 ppf: 1 ppct: 9 formats: tig: atl: Blood pressure polygenic score, cardiorespiratory fitness and odds of dementia: the HUNT Study. aug: au: Lerfald, Maren Øvretveit, Karsten Nilsen, Tom Ivar Lund Eldholm, Rannveig Sakshaug Grøtting, Nora Wolford, Brooke N Selbaek, Geir Ernstsen, Linda affil: Faculty of Medicine and Health Sciences, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, NorwayClinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Trondheim, Norway Faculty of Medicine and Health Sciences, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, NorwayClinic of Emergency Medicine and Prehospital Care, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway Faculty of Medicine and Health Sciences, Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Trøndelag, NorwayDepartment of Geriatrics, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway Faculty of Medicine and Health Sciences, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Oslo, NorwayFaculty of Medicine, University of Oslo, Oslo, NorwayDepartment of Geriatric Medicine, Oslo University Hospital, Oslo, Norway su: Norway Hypertension Sex distribution Psychological tests Dementia risk factors Risk assessment Cardiopulmonary fitness Research funding Logistic regression analysis Descriptive statistics Genetic risk score Longitudinal method Odds ratio Confidence intervals Systolic blood pressure Data analysis software Algorithms Regression analysis Disease complications sug: subj: Hypertension Sex distribution Psychological tests Norway Dementia risk factors Risk assessment Cardiopulmonary fitness Research funding Logistic regression analysis Descriptive statistics Genetic risk score Longitudinal method Odds ratio Confidence intervals Systolic blood pressure Data analysis software Algorithms Regression analysis Disease complications keyword: blood pressure cardiorespiratory fitness copyrightHolder:British Geriatrics Society copyrightYear:2026 dementia genetics https://dx.doi.org/10.1093/ageing/afag214 hunt study inLanguage:en older people polygenic score publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/42476555/ blood pressure cardiorespiratory fitness copyrightHolder:British Geriatrics Society copyrightYear:2026 dementia genetics https://dx.doi.org/10.1093/ageing/afag214 hunt study inLanguage:en older people polygenic score publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/42476555/ ab: High blood pressure (BP) is linked to an increased dementia risk. The role of sex and the impact of cardiorespiratory fitness (CRF) on the potential association between genetic predisposition to high blood pressure and dementia are less understood. Our aim was to investigate if there is an association between genetic predisposition to high systolic blood pressure (SBP) and occurrence of dementia in males and females and whether CRF modifies this association. This prospective cohort study utilised data from the population-based Trøndelag Health Study in Norway. We included 9145 participants ≥70 years in the HUNT4 70+ sub-study. The sex-specific association between the BP polygenic score (PGS) and dementia was estimated by logistic regression. Analyses were stratified by CRF to investigate potential effect modification by CRF. Among 5011 females (mean age 78.5 years) and 4134 males (mean age 77.4 years), 812 (16.2%) and 570 (13.8%) dementia cases were identified, respectively. Females in the highest fifth of the PGS had an increased odds of dementia [odds ratio (OR) = 1.45; 95% confidence interval (CI) 1.10 to 1.90]. This was not observed in males (OR = 1.03; 95% CI 0.77 to 1.37). The association was somewhat stronger in females with low fitness (OR = 1.53; 95% CI 1.08 to 2.17) than in females with high fitness (OR = 1.12; 95% CI 0.78 to 1.63). Genetic predisposition to high SBP was associated with higher odds of dementia in females, particularly if they had low CRF. Future studies should further examine sex-specific effects of genetic and modifiable factors on dementia risk. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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