Antidepressant use at the threshold: people prescribed antidepressants around the time of a dementia diagnosis.
Background Antidepressant use is common in people with dementia, and many start around the time of diagnosis. We hypothesised that those who commenced antidepressants at dementia diagnosis started for dementia-related symptoms, distinct from those with longstanding prescriptions, resulting in differ...
| Publicado en: | Age & Ageing Vol. 55; no. 7; pp. 1 - 10 |
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| Autores principales: | , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Jul2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=195867375&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 195867375 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jul2026 vid: 55 iid: 7 pid: 622 pub: Oxford University Press / USA artinfo: ui: 195867375 10.1093/ageing/afag221 ppf: 1 ppct: 9 formats: tig: atl: Antidepressant use at the threshold: people prescribed antidepressants around the time of a dementia diagnosis. aug: au: Heybe, Mohamed Verma, Shreya Moyano, Beatriz Pozuelo Stewart, Rob Mueller, Christoph Davis, Katrina A S affil: Psychological Medicine, King's College London Institute of Psychiatry Psychology & Neuroscience, London, United Kingdom Academic Psychiatry, King's College London Institute of Psychiatry Psychology & Neuroscience, London, United Kingdom Service of Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Prilly, VD, SwitzerlandDepartment of Psychiatry, University of Lausanne, Lausanne, VD, Switzerland Psychological Medicine, King's College London Institute of Psychiatry Psychology & Neuroscience, London, United KingdomNIHR Biomedical Research Centre: Maudsley, South London and Maudsley NHS Foundation Trust, London, United Kingdom NIHR Biomedical Research Centre: Maudsley, South London and Maudsley NHS Foundation Trust, London, United KingdomDepartment of Old Age Psychiatry, King's College London Institute of Psychiatry Psychology & Neuroscience, London, United Kingdom su: United Kingdom Medical quality control Mental health services Primary health care Anxiety Retrospective studies Mental depression Diagnosis of dementia Secondary care (Medicine) Research funding Multiple regression analysis Natural language processing Deprescribing Chi-squared test Descriptive statistics Antidepressants Longitudinal method Odds ratio Physician practice patterns Electronic health records Medical records Acquisition of data Drug prescribing Comparative studies Confidence intervals Data analysis software Dementia patients sug: subj: Medical quality control Mental health services Primary health care Anxiety Retrospective studies Mental depression United Kingdom Pharmaceutical and medicine manufacturing Medicinal and Botanical Manufacturing Offices of Mental Health Practitioners (except Physicians) Residential Mental Health and Substance Abuse Facilities Psychiatric and Substance Abuse Hospitals Diagnosis of dementia Secondary care (Medicine) Research funding Multiple regression analysis Natural language processing Deprescribing Chi-squared test Descriptive statistics Antidepressants Longitudinal method Odds ratio Physician practice patterns Electronic health records Medical records Acquisition of data Drug prescribing Comparative studies Confidence intervals Data analysis software Dementia patients keyword: antidepressive agents anxiety copyrightHolder:British Geriatrics Society copyrightYear:2026 dementia depression depressive disorders diagnosis electronic health records https://dx.doi.org/10.1093/ageing/afag221 inLanguage:en natural language processing older people prescribing publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/42506890/ antidepressive agents anxiety copyrightHolder:British Geriatrics Society copyrightYear:2026 dementia depression depressive disorders diagnosis electronic health records https://dx.doi.org/10.1093/ageing/afag221 inLanguage:en natural language processing older people prescribing publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/42506890/ ab: Background Antidepressant use is common in people with dementia, and many start around the time of diagnosis. We hypothesised that those who commenced antidepressants at dementia diagnosis started for dementia-related symptoms, distinct from those with longstanding prescriptions, resulting in different characteristics in electronic records. Methods We carried out a retrospective cohort study using linked primary care (Lambeth DataNet) and mental health (Clinical Record Interactive Search) data for patients with dementia in south London, UK in 2009–22. Antidepressant prescription starting within one year before or after dementia diagnosis identified as 'new'. Dementia and anxiety were described using coded fields, a rating scale for neuropsychiatric symptoms and natural language processing of full-text. Results Of 3713 patients with dementia, 28% were prescribed an antidepressant in the year of dementia diagnosis. 42% of these were 'new' prescriptions. Compared to the no antidepressant group, 'new' starters were more likely to be female (odds ratio (OR) 1.33, 95% 1.08–1.64) and have vascular dementia (OR 1.44, 1.13–1.83). Compared to longstanding antidepressant group, 'new' had similar depression and anxiety symptoms, but fewer coded mentions (OR 0.50, 0.39–0.65), especially those 'new' from non-White ethnicities. Deprescribing was equally unlikely in 'new' and longstanding (6.3% vs 5.5% per year of follow-up). Conclusion There is a high prevalence and lack of deprescribing, despite guidelines cautioning antidepressants. This points to unmet needs at the threshold of dementia. Clinicians should ensure good documentation of indication for antidepressants and proactive medication reviews for people with dementia. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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