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新型冠状病毒感染后以Balint综合征为首发 表现的克⁃雅病一例.

Objective To report the clinical diagnosis and treatment of a case of sporadic Creutzfeldt - Jakob disease (sCJD), Heidenhain variant, presenting initially with Balint syndrome following severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection, and to review relevant literature to summar...

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Publicado en:Chinese Journal of Contemporary Neurology & Neurosurgery Vol. 26; no. 7; pp. 740 - 747
Autores principales: 叶雯露, 庄圣, 徐加平, 李洁, 黄译腺
Formato: case study diagnostic images tables/charts tracings Journal Article
Publicado: Chinese Journal of Contemporary Neurology & Neurosurgery Jul2026
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jul2026
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      pub: Chinese Journal of Contemporary Neurology & Neurosurgery
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        10.3969/j.issn.1672-6731.2026.07.009
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        atl: 新型冠状病毒感染后以Balint综合征为首发 表现的克⁃雅病一例.
      aug:
        au:
          叶雯露
          庄圣
          徐加平
          李洁
          黄译腺
        affil: Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu, China
      sug:
        subj:
          Creutzfeldt-Jakob Syndrome Diagnosis
          Creutzfeldt-Jakob Syndrome Therapy
          Creutzfeldt-Jakob Syndrome Etiology
          COVID-19 Complications
          Perceptual Disorders
          China
          Male
          Aged, 80 and Over
          Brain Diseases Symptoms
          Perceptual Disorders Complications
          Perceptual Disorders Diagnosis
          Perceptual Disorders Etiology
          Prion Diseases
          Creutzfeldt-Jakob Syndrome Drug Therapy
          Magnetic Resonance Imaging
          Electroencephalography
          Agnosia
          Ocular Motility Disorders
          Myoclonus
          Carrier Proteins Cerebrospinal Fluid
          Aged, 80 & over
          Male
      ab:
        Objective To report the clinical diagnosis and treatment of a case of sporadic Creutzfeldt - Jakob disease (sCJD), Heidenhain variant, presenting initially with Balint syndrome following severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection, and to review relevant literature to summarize the clinical characteristics of this disease. Methods and Results An 81-year-old male patient was admitted to The Second Affiliated Hospital of Soochow University on August 19, 2023, with clinical manifestations of gait instability, simultanagnosia, optic ataxia, and oculomotor apraxia (Balint syndrome). The condition progressively worsened, with the development of dementia, features of cerebellar involvement, and myoclonus. Cerebrospinal fluid tested positive for 14 - 3 - 3γ protein. DWI showed cortical hyperintensities in the bilateral parieto-occipito- temporal lobes, displaying the "cortical ribbon sign". EEG revealed frequent medium-to-high amplitude slow waves predominantly in the fronto-temporal region. The final diagnosis was sCJD, Heidenhain variant, presenting initially with Balint syndrome. Treatment aimed at improving cognition and controlling myoclonus yielded a poor response. Twenty days after discharge, the patient developed akinetic mutism and dyspnea, ultimately succumbing to respiratory failure. Conclusions Balint syndrome is a rare initial clinical manifestation of sCJD, warranting early recognition. SARS-CoV-2 infection may potentially trigger or accelerate the progression of sCJD.
        目的回顾1 例新型冠状病毒感染后以Balint综合征为首发表现的Heidenhain 变异型散 发型克⁃雅病患者的临床资料，并复习相关文献，总结疾病的临床特征。方法与结果苏州大学附属第 二医院于2023年8月19日收治1例81岁男性患者，临床表现为行走不稳、同时性失认、视觉性共济失调 和眼动性失用，随后病情快速进展，出现痴呆、小脑受累和肌阵挛；脑脊液14⁃3⁃3γ蛋白阳性；头部MRI显 示双侧顶枕颞叶皮质DWI高信号，呈“花边征”；脑电图呈现以额颞区为主的较多中高波幅慢波，最终诊 断为以Balint综合征为首发表现的Heidenhain 变异型散发型克⁃雅病。予以改善认知功能、控制肌阵挛 等治疗，疗效欠佳。出院20 d后出现无动性缄默和呼吸困难，最终因呼吸衰竭死亡。结论Balint综合 征是散发型克⁃雅病的罕见表现，应注意早期识别。新型冠状病毒感染可能诱发或加速散发型克⁃雅病 进展。
      pubtype: Academic Journal
      doctype:
        case study
        diagnostic images
        tables/charts
        tracings
        Journal Article
      ougenre: Article
    language: Chinese
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