Effects of Neurodevelopmental Disorders on the Clinical Presentations and Therapeutic Outcomes of Children and Adolescents with Severe Mood Disorders: A Multicenter Observational Study.
Individuals with neurodevelopmental disorders (NDDs) are more susceptible to developing severe or resistant mood disorders. However, they often face challenges in accessing specific treatments. To understand the barriers to treatment in this group, we conducted a secondary analysis of a multicenter...
| Publicado en: | Child Psychiatry & Human Development Vol. 57; no. 4; pp. 1101 - 1112 |
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| Autores principales: | , , , , , , |
| Formato: | Artículo |
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Springer Nature
Aug2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=195896169&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 195896169 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 0009398X CPH jtl: Child Psychiatry & Human Development issn: 0009398X maglogo: N pubinfo: dt: Aug2026 vid: 57 iid: 4 pid: 237 pub: Springer Nature artinfo: ui: 195896169 10.1007/s10578-024-01770-7 ppf: 1101 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P size: 1.1MB tig: atl: Effects of Neurodevelopmental Disorders on the Clinical Presentations and Therapeutic Outcomes of Children and Adolescents with Severe Mood Disorders: A Multicenter Observational Study. aug: au: Benarous, Xavier Lefebvre, Chloé Guilé, Jean-Marc Consoli, Angèle Cravero, Cora Cohen, David Lahaye, Hélène affil: https://ror.org/02en5vm52 Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière University Hospital, APHP, Sorbonne Université, 83 boulevard de l'Hôpital, 75013, Paris, France https://ror.org/02qqh1125 Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLesp), Equipe de Recherche en Epidémiologie Sociale (ERES), Paris, France https://ror.org/010567a58 Department of Child and Adolescent Psychopathology, Amiens University Hospital, Amiens, France https://ror.org/01gyxrk03 INSERM Unit U1105 Research Group for Analysis of the Multimodal Cerebral Function, University of Picardy Jules Verne (UPJV), Amiens, France Pôle de Psychiatrie de L'Enfant et de L'Adolescent, Etablissement Publique de Santé Mentale de la Somme, Amiens, France Interdepartmental Mobile Unit for Complex Situations in Autism (UMI 75-92), Elan Retrouvé Foundation, Paris, France https://ror.org/02en5vm52 CNRS UMR 7222, Institute for Intelligent Systems and Robotics, Sorbonne University, Paris, France su: Affective disorders Teenagers Cohort analysis Treatment effectiveness Neural development Symptoms sug: subj: Affective disorders Teenagers Cohort analysis Treatment effectiveness Neural development Symptoms keyword: Behavioral problems Emotional dysregulation Hospitalization Irritability Medical and Health Sciences Clinical Sciences Mood dysregulation Behavioral problems Emotional dysregulation Hospitalization Irritability Medical and Health Sciences Clinical Sciences Mood dysregulation ab: Individuals with neurodevelopmental disorders (NDDs) are more susceptible to developing severe or resistant mood disorders. However, they often face challenges in accessing specific treatments. To understand the barriers to treatment in this group, we conducted a secondary analysis of a multicenter observational study on 305 adolescents referred to specialized care (mean age 14.38 ± 0.13 years, 57% girls, 9% bipolar disorder, 91% depressive disorders). NDDs were categorized based on the number of co-occurring NDDs for each subject (none: 67%, one: 18%, two: 7%, three: 5%, four and more: 2%). We explored the predictive value of the number of NDDs on various clinical and therapeutic factors. The analysis revealed significant associations between the number of NDDs and the duration of mood symptoms, persistent irritability, associated disruptive behavioral disorders, lower scores on the Children's Global Assessment Scale (CGAS) at baseline, and polypharmacy. The number of NDDs did not correlate with the use of antidepressants, the Clinical Global Impression-Improvement scale (CGI-I) at discharge, or changes in the CGAS score during the stay. The challenges in distinguishing mood disorders from chronic emotional and behavioral difficulties may contribute to the difficulties in accessing specific care for mood disorders. These results suggest that treatments for mood disorders demonstrate comparable effectiveness when provided regardless of the associations with NDDs. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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