Young adult urbanicity, late midlife neighborhood disadvantage, and cognitive functioning in community-dwelling older men.

Objectives Early-life rural-urban residence has been linked to differences in later-life cognitive functioning and dementia risk. However, the contextual pathways underlying these associations, particularly emergent associations later in life, remain underexplored. We examined the associations betwe...

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Publicado en:Journals of Gerontology Series B: Psychological Sciences & Social Sciences Vol. 81; no. 8; pp. 1 - 13
Autores principales: Tang, Rongxiang, Beck, Asad, Gustavson, Daniel E, Eyler, Lisa T, Elman, Jeremy A, Bell, Tyler R, Buchholz, Erik, Hunt, Jack F V, Vo, Tina T, Fennema-Notestine, Christine
Formato: Artículo
Publicado: Oxford University Press / USA Aug2026
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Acceso en línea:Ver este registro en EBSCOhost
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      dt: Aug2026
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      pub: Oxford University Press / USA
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        10.1093/geronb/gbag093
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        atl: Young adult urbanicity, late midlife neighborhood disadvantage, and cognitive functioning in community-dwelling older men.
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          Tang, Rongxiang
          Beck, Asad
          Gustavson, Daniel E
          Eyler, Lisa T
          Elman, Jeremy A
          Bell, Tyler R
          Buchholz, Erik
          Hunt, Jack F V
          Vo, Tina T
          Fennema-Notestine, Christine
        affil:
          Department of Psychological and Brain Sciences, Texas A&M University, College Station, Texas, United States
          Department of Biology, University of Washington, Seattle, Washington, United States
          Institute for Behavioral Genetics and Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, United States
          Department of Psychiatry, University of California San Diego, La Jolla, California, United States
          Department of Psychiatry, University of California San Diego, La Jolla, California, United StatesCenter for Behavior Genetics of Aging, University of California San Diego, La Jolla, California, United States
          Department of Psychiatry, University of California San Diego, La Jolla, California, United StatesDepartment of Psychiatry, University of Washington, Seattle, United States
          Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, California, United StatesDepartment of Radiology, University of California San Diego, La Jolla, California, United States
      su:
        United States
        Income
        Socioeconomic factors
        Residential patterns
        Executive function
        Rural population
        Psychological tests
        Cognition
        Old age
        Pearson correlation (Statistics)
        Independent living
        Data analysis
        Research funding
        Scientific observation
        Probability theory
        Descriptive statistics
        Longitudinal method
        Statistics
        Factor analysis
        Data analysis software
        Neighborhood characteristics
      sug:
        subj:
          Income
          Socioeconomic factors
          Residential patterns
          Executive function
          Rural population
          Psychological tests
          Cognition
          Old age
          United States
          Pearson correlation (Statistics)
          Independent living
          Data analysis
          Research funding
          Scientific observation
          Probability theory
          Descriptive statistics
          Longitudinal method
          Statistics
          Factor analysis
          Data analysis software
          Neighborhood characteristics
      keyword:
        adult
        aged
        area deprivation index
        cognition
        cognitive ability
        community
        copyrightHolder:The Gerontological Society of America
        copyrightYear:2026
        dementia
        episodic memory
        executive functioning
        https://dx.doi.org/10.1093/geronb/gbag093
        inLanguage:en
        limbic-predominant age-related tdp-43 encephalopathy
        mental processes
        middle-aged adult
        neighborhood
        neighborhood disadvantage
        Processing speed
        publisher:Oxford University Press
        Rural
        sameAs:https://pubmed.ncbi.nlm.nih.gov/42178222/
        Urban
        verbal fluency
        visuospatial ability
        young adult
        adult
        aged
        area deprivation index
        cognition
        cognitive ability
        community
        copyrightHolder:The Gerontological Society of America
        copyrightYear:2026
        dementia
        episodic memory
        executive functioning
        https://dx.doi.org/10.1093/geronb/gbag093
        inLanguage:en
        limbic-predominant age-related tdp-43 encephalopathy
        mental processes
        middle-aged adult
        neighborhood
        neighborhood disadvantage
        Processing speed
        publisher:Oxford University Press
        Rural
        sameAs:https://pubmed.ncbi.nlm.nih.gov/42178222/
        Urban
        verbal fluency
        visuospatial ability
        young adult
      ab: Objectives Early-life rural-urban residence has been linked to differences in later-life cognitive functioning and dementia risk. However, the contextual pathways underlying these associations, particularly emergent associations later in life, remain underexplored. We examined the associations between young adult urbanicity and domain-specific cognition in older adulthood and whether late midlife neighborhood socioeconomic disadvantage may mediate such associations. Methods Participants were 881 community-dwelling men aged 61–73 from across the United States. Young adult urbanicity (rural, suburban, and urban) was assessed at a mean age of 20 based on the Rural-Urban Continuum Codes. Late midlife neighborhood disadvantage was indexed by the area deprivation index (ADI), and cognitive performance in older adulthood was assessed in five domains: executive function, episodic memory, processing speed, verbal fluency, and visual-spatial ability. Results Compared to those in rural areas, participants who resided in urban areas during young adulthood had lower late midlife ADI (β = −0.85, p <.05), and better executive function (β = 0.19), processing speed (β = 0.24), and verbal fluency (β = 0.30) (ps <.05) in older adulthood. ADI partially mediated these associations, such that urban residence was associated with lower ADI, which was then associated with better performance in these three domains (indirect effects: βs = 0.02 to 0.03). Discussion Late midlife neighborhood disadvantage represents a contextual pathway linking early-life rural-urban residence to cognitive function in older adulthood. Reducing socioeconomic disadvantage through health policies and interventions at both the community-level early in life and the neighborhood-level later in life may help reduce the risk of cognitive impairment and dementia.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
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