Purpose in life and blood-based biomarkers of brain health.
Objectives Purpose in life is associated consistently with better cognitive outcomes. The association between purpose and neurobiomarkers of brain health has been less robust than the association with cognitive outcomes. This research uses the largest sample to date to test the association between p...
| Publicado en: | Journals of Gerontology Series B: Psychological Sciences & Social Sciences Vol. 81; no. 8; pp. 1 - 10 |
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| Autores principales: | , , , |
| Formato: | Artículo |
| Publicado: |
Oxford University Press / USA
Aug2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=195931924&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 195931924 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 10795014 JGB jtl: Journals of Gerontology Series B: Psychological Sciences & Social Sciences issn: 10795014 maglogo: N pubinfo: dt: Aug2026 vid: 81 iid: 8 pid: 622 pub: Oxford University Press / USA artinfo: ui: 195931924 10.1093/geronb/gbag105 ppf: 1 ppct: 9 formats: tig: atl: Purpose in life and blood-based biomarkers of brain health. aug: au: Sutin, Angelina R Luchetti, Martina Stephan, Yannick Terracciano, Antonio affil: Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee, Florida, United States Euromov, University of Montpellier, Montpellier, France Department of Geriatrics, Florida State University College of Medicine, Tallahassee, Florida, United States su: Psychological adaptation Psychological well-being Sociodemographic factors Cognition Middle age Old age Statistical correlation Statistical power analysis Tau proteins Alzheimer's disease Research funding Brain Blood collection Descriptive statistics Cytoskeletal proteins Neurodegeneration Nerve tissue proteins Research Statistics Dementia Biomarkers Regression analysis Amyloid beta-protein precursor sug: subj: Psychological adaptation Psychological well-being Sociodemographic factors Cognition Middle age Old age Statistical correlation Statistical power analysis Tau proteins Alzheimer's disease Research funding Brain Blood collection Descriptive statistics Cytoskeletal proteins Neurodegeneration Nerve tissue proteins Research Statistics Dementia Biomarkers Regression analysis Amyloid beta-protein precursor keyword: ADRD biomarkers biological markers brain cognitive ability copyrightHolder:The Gerontological Society of America copyrightYear:2026 glial fibrillary acidic protein https://dx.doi.org/10.1093/geronb/gbag105 inLanguage:en Neuronal injury neuropathology psychological publisher:Oxford University Press resilience sameAs:https://pubmed.ncbi.nlm.nih.gov/42281408/ sense of purpose sociodemographic factors Well-being ADRD biomarkers biological markers brain cognitive ability copyrightHolder:The Gerontological Society of America copyrightYear:2026 glial fibrillary acidic protein https://dx.doi.org/10.1093/geronb/gbag105 inLanguage:en Neuronal injury neuropathology psychological publisher:Oxford University Press resilience sameAs:https://pubmed.ncbi.nlm.nih.gov/42281408/ sense of purpose sociodemographic factors Well-being ab: Objectives Purpose in life is associated consistently with better cognitive outcomes. The association between purpose and neurobiomarkers of brain health has been less robust than the association with cognitive outcomes. This research uses the largest sample to date to test the association between purpose in life and four neurobiomarkers of brain health measured from plasma: The Aβ42/Aβ40 ratio, p-tau181, neurofilament light (NfL), and glial fibrillary acidic protein. We further test whether higher purpose is associated with cognitive resilience against neuropathological burden (i.e. better cognitive performance relative to the amount of neuropathology). Methods Data were from the Health and Retirement Study. Participants (N = 4,193; M = 68.87, SD = 10.17) reported on their purpose in life and provided venous blood. Biomarkers were assessed using Quanterix's Simoa platforms. Linear regression tested the association between purpose and the four neurobiomarkers. Residual and interaction-based approaches evaluated cognitive resilience. Results Purpose in life was associated with lower NfL accounting for sociodemographic factors (β = −0.06, p <.001). Clinical and behavioral covariates accounted for half of this association, but it persisted (β = −0.03, p =.007). Purpose was unrelated to the other three neurobiomarkers. Purpose in life was associated with greater cognitive resilience when tested with the residual approach (β = 0.12, p <.001) but not the interaction approach (β = 0.01, p =.372). Discussion In the largest sample to date, individuals with more purpose in life had less neuronal injury, as measured with NfL. Purpose was unrelated to other common neurobiomarkers of brain health. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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