Cortical Response and Functional Connectivity in Patients With Subacute Stroke During Dual Task: An fNIRS Study.
To investigate neural plasticity changes in patients with subacute stroke during single motor task and dual-task execution. Case-control study. Rehabilitation department in a single hospital. Twenty patients with subacute stroke (mean age, 63.8±10.4y; Mini-Mental State Examination score >20) and 20...
| Publicado en: | Archives of Physical Medicine & Rehabilitation Vol. 107; no. 8; pp. 2045 - 2056 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
W B Saunders
Aug2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195995867&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195995867 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039993 1XL jtl: Archives of Physical Medicine & Rehabilitation issn: 00039993 maglogo: N pubinfo: dt: Aug2026 vid: 107 iid: 8 pid: 1351 pub: W B Saunders place: Philadelphia, Pennsylvania artinfo: ui: 195995867 195995867 195995867 10.1016/j.apmr.2026.01.003 195995867 ppf: 2045 ppct: 11 formats: tig: atl: Cortical Response and Functional Connectivity in Patients With Subacute Stroke During Dual Task: An fNIRS Study. aug: au: Liu, Wu Huo, Congcong Zhang, Simin Zhang, Xuemin Shao, Guangjian Chen, Tiandi Liu, Jizhong Li, Zengyong affil: School of Advanced Manufacturing, NanChang University, NanChang sug: subj: Cerebral Cortex Physiology Stroke Rehabilitation Task Performance and Analysis Evaluation Functional Connectivity Evaluation Spectroscopy, Near-Infrared Methods Stroke Patients Neuronal Plasticity Human Descriptive Statistics Case Control Studies Psychological Tests Convenience Sample Hemodynamics Motor Skills Sensory Motor Integration Cognition Paradigms ab: To investigate neural plasticity changes in patients with subacute stroke during single motor task and dual-task execution. Case-control study. Rehabilitation department in a single hospital. Twenty patients with subacute stroke (mean age, 63.8±10.4y; Mini-Mental State Examination score >20) and 20 age- and sex-matched healthy controls (mean age, 60.95±9.5y) recruited via convenience sampling. Not applicable. A functional near-infrared spectroscopy (fNIRS) system was used to evaluate hemodynamic responses in prefrontal, motor, and occipital regions during single motor task and motor-cognitive dual-task conditions, and functional connectivity (FC) was calculated for each task state. Healthy controls showed widespread activation increases during dual-task versus single motor task (P <.05), whereas patients with stroke exhibited enhanced activation only in ipsilesional prefrontal cortex (P =.041) and contralesional supplementary motor area (P =.045). Controls demonstrated significantly higher sensorimotor activation than patients with stroke during dual-task (P =.001). FC analysis revealed increased prefrontal-premotor connectivity in controls (P =.027), whereas patients with stroke showed enhanced bilateral prefrontal (P =.032), premotor (P =.034), and occipital (P =.043) connectivity. In patients with stroke, premotor area activation is negatively correlated with pace (ρ=−0.53, P =.025), heel-strike angle (ρ=−0.73, P =.029), and swing phase (ρ=−0.56, P =.015), but positively with support phase (ρ=0.56, P =.015). This study confirms that motor-cognitive dual task paradigms effectively induce activation in the ipsilesional cortex of patients with stroke while enhancing interhemispheric FC, demonstrating significant neuromodulatory effects of dual-task training in stroke rehabilitation; simultaneously, it validates the feasibility of utilizing fNIRS combined with motor paradigms for real-time assessment of neuroplasticity changes. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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