Unmet needs for lipid management in patients with peripheral arterial disease: A narrative review.
Lower extremity peripheral arterial disease (PAD) is a prevalent manifestation of systemic atherosclerosis associated with significant morbidity, mortality, and economic burden. Lipid-lowering therapy (LLT) with high-intensity statins and nonstatin therapies is a cornerstone of guideline-directed ma...
| Publicado en: | Journal of Clinical Lipidology Vol. 20; no. 7; pp. 1312 - 1325 |
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| Autores principales: | , , |
| Formato: | review Journal Article |
| Publicado: |
Elsevier B.V.
Jul2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195999435&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195999435 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19332874 54Y0 jtl: Journal of Clinical Lipidology issn: 19332874 maglogo: N pubinfo: dt: Jul2026 vid: 20 iid: 7 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 195999435 195999435 195999435 10.1016/j.jacl.2026.04.016 195999435 ppf: 1312 ppct: 13 formats: tig: atl: Unmet needs for lipid management in patients with peripheral arterial disease: A narrative review. aug: au: Bolden, Demetria M. Cheeley, Mary Katherine Tedder, Barry Craig affil: School of Medicine, Division of General Internal Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA sug: subj: Health Services Needs and Demand Lipoproteins, LDL Cholesterol Blood Peripheral Vascular Diseases Drug Therapy Antilipemic Agents Therapeutic Use Implementation Science Lower Extremity Pathology Social Class Disease Progression Prevention and Control Quality of Life Treatment Outcomes Undertreatment ab: Lower extremity peripheral arterial disease (PAD) is a prevalent manifestation of systemic atherosclerosis associated with significant morbidity, mortality, and economic burden. Lipid-lowering therapy (LLT) with high-intensity statins and nonstatin therapies is a cornerstone of guideline-directed management to reduce the risk of major adverse limb and cardiovascular events. Despite robust evidence and clear guideline recommendations, the utilization of LLT in patients with PAD remains suboptimal. We review evidence that highlights gaps in lipid management for patients with PAD, and how these may be addressed by leveraging implementation science. A large proportion of patients with PAD do not receive recommended LLT and subsequently do not achieve low-density lipoprotein cholesterol (LDL-C) goals. These patients are at risk of major adverse cardiovascular and limb events, including preventable amputations. Health inequities can further exacerbate the underutilization of LLT. While there is a paucity of studies specifically evaluating the effectiveness of implementation strategies for lipid management in patients with PAD, we propose approaches that are grounded in evidence from broader populations with other forms of atherosclerotic cardiovascular disease. There is a clear and urgent need for better implementation strategies to ensure optimal care is provided to patients with PAD, regardless of race, ethnicity, or socioeconomic status. Addressing the underutilization of guideline-recommended LLT in PAD requires multifaceted approaches considering healthcare systems, clinicians, and patients' needs. By ensuring that all patients with PAD receive appropriate LLT to achieve guideline-directed LDL-C goals, we can hope to substantially improve their cardiovascular outcomes and quality of life. • PAD is a manifestation of systemic atherosclerosis associated with CV events, amputations, and reduced quality of life. • Lipid-lowering therapy (LLT) is a cornerstone of medical management to prevent disease progression and complications. • Many patients do not receive LLT despite guideline recommendations, and subsequently do not achieve LDL-C goals. • Health inequities drive differences in the prevalence of PAD, access to high-quality care, and rates of amputation. • Further research is needed on implementation strategies for lipid management in PAD to improve clinical outcomes. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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