Injectable Gelatin–Farsi Gum Hydrogels Functionalized With Hydroxyapatite for Biomimetic Oral Bone Regeneration.
Objective: Bone repair requires injectable biomaterials that solidify in situ, resist infection, and provide osteoconductive reinforcement. However, it remains unknown whether a photo‐crosslinkable hydrogel can combine silver nanoparticle functionality with hydroxyapatite‐driven mechanical support f...
| Publicado en: | BioMed Research International Vol. 2026; pp. 1 - 15 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | diagnostic images equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
8/7/2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=196035978&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 196035978 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 8/7/2026 vid: 2026 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 196035978 196035978 196035978 10.1155/bmri/6156533 196035978 ppf: 1 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Injectable Gelatin–Farsi Gum Hydrogels Functionalized With Hydroxyapatite for Biomimetic Oral Bone Regeneration. aug: au: Amiri, Mohammad Amin Abedanzadeh, Mozhgan Daneshi, Seyyed Sajad Najibi, Asma Zarei, Moein Afzoon, Saeed Akbarizadeh, Fatemeh Kazemi, Radmehr Fereidouni, Kiarash Norouzi, Mohammad Niknezhad, Seyyed Vahid Lavaee, Fatemeh Klug, Yoel A. affil: Oral and Dental Disease Research Center,, Shiraz University of Medical Sciences,, Shiraz, Iran, sums.ac.ir sug: subj: Bone Regeneration Drug Effects Proteins Pharmacodynamics Gels Pharmacodynamics Hydroxyapatites Chewing Gum Pharmacodynamics Injections Biocompatible Materials Silver Infection Mandible Drug Effects Animal Studies Rats Models, Biological Funding Source Tissue Engineering Physics Spectrophotometry, Infrared Edema Data Analysis Software Descriptive Statistics ab: Objective: Bone repair requires injectable biomaterials that solidify in situ, resist infection, and provide osteoconductive reinforcement. However, it remains unknown whether a photo‐crosslinkable hydrogel can combine silver nanoparticle functionality with hydroxyapatite‐driven mechanical support for mandibular regeneration. Methods: An injectable hydrogel was synthesized from gelatin methacrylate and methacrylated Farsi gum, functionalized with silver nanoparticles and hydroxyapatite (0%, 5%, and 10% w/w). Chemistry and phase integration were verified by Fourier‐transform infrared spectroscopy, x‐ray diffraction, and proton nuclear magnetic resonance; swelling, degradation, porosity, and compression (including cyclic loading) were assessed at 5 and 12 weeks using radiography and histology; and rat mandibular healing was assessed at 5 and 12 weeks by radiography and histology. Results: Spectroscopic and diffraction analyses confirmed incorporation of all components. All formulations showed controlled swelling/degradation with porous architectures. Hydroxyapatite increased compressive performance, with 10% w/w yielding the highest strength and elastic recovery under repeated compression. In rat mandibles, the 10% hydroxyapatite hydrogel supported bone regeneration on radiographic and histologic assessment at Weeks 5 and 12. Conclusions: These data show a single injectable platform that combines antimicrobial and anti‐inflammatory functions with osteoconductive support, paving the way for minimally invasive craniofacial and orthopedic bone repair. pubtype: Academic Journal doctype: diagnostic images equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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